Results 51 to 60 of about 2,779,849 (194)

Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases

Molecular Therapy: Nucleic Acids
RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni, Alessia Bibi, Alisia Madé, Shubhra Acharya, Mikko Parkkonen, Teodora Barbalata, Prashant K. Srivastava, David de Gonzalo-Calvo, Constanza Emanueli, Fabio Martelli, Yvan Devaux, Dimitra Dafou, A. Yaël Nossent   +12 more
doaj   +1 more source

A-to-I RNA editing and hematopoiesis

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang, Carl R, Walkley, Jacki E, Heraud-Farlow   +2 more
openaire   +2 more sources

Adaptation of A-to-I RNA editing in Drosophila

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Yuange Duan, Shengqian Dou, Shiqi Luo, Hong Zhang, Jian Lu   +4 more
openaire   +4 more sources

Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori

Insects, 2020
The most common type of RNA editing in metazoans is the deamination of adenosine into inosine (A-to-I) catalyzed by the adenosine deaminase acting on the RNA (ADAR) family of proteins.
Chongjun Ye, Song Jiang, Meixia Gong, Qin Min, Manli Fan, Junshan Gao, Yan Meng   +6 more
doaj   +1 more source

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

Cancer Cell International, 2018
Background RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity.
Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng, Huimin Hu   +7 more
doaj   +1 more source

An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites

RNA Biology
Adar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu, Tianyou Zhao, Caiqing Zheng, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan   +8 more
doaj   +1 more source

Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes

Genome Biology, 2021
Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability.
Eddie Park, Yan Jiang, Lili Hao, Jingyi Hui, Yi Xing   +4 more
doaj   +1 more source

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]

, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Cattenoz, Pierre B., Mattick, John S., Taft, Ryan J., Westhof, Eric   +3 more
core   +2 more sources

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Cell Reports, 2021
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait   +11 more
doaj   +1 more source

Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites

Fly
Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan, Ling Ma, Tianyou Zhao, Jiyao Liu, Caiqing Zheng, Fan Song, Li Tian, Wanzhi Cai, Hu Li   +8 more
doaj   +1 more source