Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor [PDF]
Frontiers in Psychiatry, 2021 Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju +6 more
doaj +3 more sources
A1 Adenosine Receptor Signaling Reduces Streptococcus pneumoniae Adherence to Pulmonary Epithelial Cells by Targeting Expression of Platelet-Activating Factor Receptor [PDF]
Cell Microbiol, 2019 Extracellular adenosine production is crucial for host resistance against Streptococcus pneumoniae (pneumococcus) and is thought to affect antibacterial immune responses by neutrophils. However, whether extracellular adenosine alters direct host-pathogen
Manmeet Bhalla +6 more
semanticscholar +2 more sources
Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]
Journal of Histochemistry & Cytochemistry, 2000 The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
Alba Minelli +5 more
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Adenosine Deaminase and A1 Adenosine Receptors Internalize Together following Agonist-induced Receptor Desensitization [PDF]
Journal of Biological Chemistry, 1998 A1 adenosine receptors (A1Rs) and adenosine deaminase (ADA; EC 3.5.4. 4) interact on the cell surface of DDT1MF-2 smooth muscle cells. The interaction facilitates ligand binding and signaling via A1R, but it is not known whether it has a role in homologous desensitization of A1Rs. Here we show that chronic exposure of DDT1MF-2 cells to the A1R agonist,
Carlos A. Saura +4 more
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A1 adenosine receptors mediate hypoglycemia-induced neuronal injury [PDF]
Journal of Molecular Endocrinology, 2004 The cellular mechanisms that lead to neuronal death following glucose deprivation are not known, although it is recognized that hypoglycemia can lead to perturbations in intracellular calcium ([Ca2+]i) levels. Recently, activation of A1 adenosine receptors (A1AR) has been shown to alter [Ca2+]i and promote neuronal death.
CP Turner +2 more
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A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic? [PDF]
Front Pharmacol, 2020 Fabrizio Vincenzi +6 more
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Chaperoning of the A1-Adenosine Receptor by Endogenous Adenosine—An Extension of the Retaliatory Metabolite Concept [PDF]
Mol Pharmacol, 2015 Justyna Kusek +5 more
semanticscholar +2 more sources
NeuroImage, 2023 The EEG alpha rhythm (∼ 8–13 Hz) is one of the most salient human brain activity rhythms, modulated by the level of attention and vigilance and related to cerebral energy metabolism.
Naemi L. Tichelman +12 more
doaj +1 more source
Frontiers in Physiology, 2023 Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu +5 more
doaj +1 more source