Results 91 to 100 of about 1,621,127 (284)

Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery.

PLoS ONE, 2014
BackgroundIncreased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the endogenous adenosine neuromodulatory role, in mesenteric arteries from normotensive ...
Joana Beatriz Sousa, Maria Sofia Vieira-Rocha, Carlos Sá, Fátima Ferreirinha, Paulo Correia-de-Sá, Paula Fresco, Carmen Diniz   +6 more
doaj   +1 more source

Age-related changes in cardiac adenosine receptor expression

, 2004
Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to adenosine decline with age.
Jenner, Tamsin L., Mellick, AS, Mellick, Albert S., Jenner, TL, Rose’Meyer, Roselyn B., Harrison, Glenn J., Griffiths, Lyn R., Griffiths, LR, Harrison, GJ, Rose'Meyer, RB   +9 more
core   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic and Parvalbumin Neurons in mice

Frontiers in Neurology, 2013
Coffee and tea contain the stimulants caffeine and theophylline. These compounds act as antagonists of adenosine receptors. Adenosine promotes sleep and its extracellular concentration rises in association with prolonged wakefulness, particularly in the ...
Chun eYang, Serena eFranciosi, Serena eFranciosi, Ritchie Edward Brown   +3 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Stimulates Glutamate Release From Astrocytes via A2a Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj   +1 more source

Atividade antinociceptiva da inosina em camundongos: participação dos receptores A1 e A2A [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA inosina, um nucleosídeo endógeno, e o primeiro metabolito da adenosina, e e sintetizada atraves da adenosina pela ...
Nascimento, Francisney Pinto do
core  

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Adenosine A_2A receptor binding profile of two antagonists, ST1535 and KW6002: consideration on the presence of atypical adenosine A_2A binding sites

Frontiers in Psychiatry, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Teresa Riccioni, Fabiana Leonardi, Franco Borsini   +2 more
doaj   +1 more source

Efficient Synthesis of AMP579, a Novel Adenosine A1/A2 Receptor Agonist

, 2016
Efficient Synthesis of AMP579, a Novel Adenosine A1/A2 Receptor ...
Tory H. Powner (3026433), Larry K. Truesdale (3026427), Adam W. Sledeski (3026424), Gregory G. Kubiak (3026430), Michael K. O'Brien (2717263), Matthew R. Powers (3026421)   +5 more
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source