Results 111 to 120 of about 1,621,127 (284)

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe, Ei‐ichiro Takaoka, Kanako Matsuoka, Shingo Kimura, Anne M. Robertson, Edwin K. Jackson, Lori A. Birder, Minoru Miyazato, Naoki Yoshimura   +8 more
wiley   +1 more source

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A₁ Adenosine Receptor Positive Allosteric Modulators. [PDF]

ACS Med Chem Lett, 2023
Oliva P, Suresh RR, Pasquini S, Salmaso V, Will EJ, Tosh DK, Gao ZG, Liu N, Gavrilova O, Vincenzi F, Varani K, Jacobson KA.   +11 more
europepmc   +1 more source

Allosteric Modulators of the A1 Adenosine receptor

, 2011
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain
ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, A. R. Moorman   +2 more
core  

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Affinity and selectivity of tecadenoson, 2-chloro-tecadenoson and 2’-C-methyl analogues at bovine and pig A1 adenosine receptor

, 2005
Adenosine A1 receptor agonists have a great interest as neuroprotective agents for the treatment of glutamate-related neurodegenerative disorders and as antilipolytic agents.
PASQUALINI M., COSTA B., FRANCHETTI, Palmarisa, KLOTZ K., CAPPELLACCI, Loredana, VITA, PATRIZIA, PETRELLI, Riccardo, MARTINI C., SPINETTI F., LAVECCHIA A., GRIFANTINI, Mario   +10 more
core   +1 more source

N6-substituted C5′-modified adenosines as A1 adenosine receptor agonists

, 2008
N6-substituted C5′-modified adenosines as A1 adenosine receptor ...
S Baker (9861626), Sally Hutchinson (13051977), Trent Ashton (13097196), Peter Scammells (13051092)   +3 more
core  

Cloning and functional characterization of a human A1 adenosine receptor.

, 1992
A human brain hippocampus cDNA library was screened by hybridization with a dog A1 adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 residue open reading frame encoding a 326 amino acid polypeptide showing 95.7 ...
Libert, Frédérick, Czernilofsky, A, Dumont, Jacques, Lefort, Anne, Ensinger, H A, Mendla, K D, Vassart, Gilbert, Van Sande, Jacqueline   +7 more
core   +1 more source