Results 31 to 40 of about 83,344 (312)
Dual acting antioxidant A1 adenosine receptor agonists
Bioorganic & Medicinal Chemistry Letters, 2007 Herein we report the synthesis and biological evaluation of some potent and selective A(1) adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety. N(6)-(2,2,5,5-Tetramethylpyrrolidin-1-yloxyl-3-ylmethyl)adenosine (VCP28, 2e) proved to be an agonist with high affinity (K(i)=50nM) and good selectivity (A ...
Gregg, Alison +8 more
openaire +3 more sources
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno +5 more
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陆军军医大学学报Objective To explore the expression profile of adenosine A1 receptor in the paraventricular thalamic nucleus (PVT) in wakefulness/sleep state and its role in regulating sleep.
ZHU Yifeng, WANG Na, HU Junya
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On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity
BMC Research Notes, 2023 Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given.
Helena D. Janse van Rensburg +2 more
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Frontiers in Pharmacology, 2016 Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP on A1 receptor-mediated inhibition of synaptic transmission remains
Isa ePinto +5 more
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Neural Regeneration Research, 2017 The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate ischemic brain insult.
Qin-xue Dai +7 more
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Anticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizures. [PDF]
PLoS ONE, 2013 Epilepsy is a chronic neurological disorder characterized by recurrent seizures. However, approximately one-third of epilepsy patients still suffer from uncontrolled seizures. Effective treatments for epilepsy are yet to be developed. N (6)-(3-methoxyl-4-
Min Li +4 more
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The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Central adenosinergic system and its clinical importance
Psychiatry and Clinical Psychopharmacology, 2021 Adenosine is a neuromodulator widely distributed throughout the body. Since it is continuously synthesized, it can be concluded that there is a basal adenosinergic tonus, which has inhibitory effects in general.
Hakan Kayır, I. Tayfun Uzbay
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