Results 81 to 90 of about 83,344 (312)

Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms

Frontiers in Pharmacology
Purinergic signaling has been implicated in many biological functions, including development. In this study, we investigate the functions of extracellular adenosine and adenosine receptors using a mouse embryonic stem cell (ESC) line and morula stages ...
Talita Glaser, Patrícia Martins, Renata Beco, Carolina Adriane Bento, Angelica R. Cappellari, Sophia La Banca Oliveira, Christian Albert Merkel, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Ana Maria Battastini, Henning Ulrich   +10 more
doaj   +1 more source

Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay [PDF]

, 2023
Luisa Saecker, Hanns Häberlein, Sebastian Franken   +2 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery.

PLoS ONE, 2014
BackgroundIncreased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the endogenous adenosine neuromodulatory role, in mesenteric arteries from normotensive ...
Joana Beatriz Sousa, Maria Sofia Vieira-Rocha, Carlos Sá, Fátima Ferreirinha, Paulo Correia-de-Sá, Paula Fresco, Carmen Diniz   +6 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic and Parvalbumin Neurons in mice

Frontiers in Neurology, 2013
Coffee and tea contain the stimulants caffeine and theophylline. These compounds act as antagonists of adenosine receptors. Adenosine promotes sleep and its extracellular concentration rises in association with prolonged wakefulness, particularly in the ...
Chun eYang, Serena eFranciosi, Serena eFranciosi, Ritchie Edward Brown   +3 more
doaj   +1 more source

Repeatability of Rapid Human Cardiac Phosphorus MRSI (31P‐MRSI) Using Concentric Ring Trajectory Readouts at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose PCr/ATP ratio is determined at 7 T typically using Fourier‐transform based magnetic resonance spectroscopic imaging sequences (FT‐MRSI). These sequences require acquisition times longer than desirable for inclusion in cardiac clinical trials. Concentric ring trajectory (CRT‐MRSI) has been described as an accelerated alternative k‐space
Ferenc E. Mózes, William T. Clarke, Andrew Tyler, Jabrane Karkouri, Fabian Niess, Jack J. J. J. Miller, Christopher T. Rodgers, Wolfgang Bogner, Ladislav Valkovič   +8 more
wiley   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Stimulates Glutamate Release From Astrocytes via A2a Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj   +1 more source

A1 adenosine receptor activation inhibits P2X3 receptor-mediated ATP currents in rat dorsal root ganglion neurons [PDF]

, 2022
Jia‐Wei Hao, Wen‐Long Qiao, Qing Li, Shuang Wei, Xuemei Li, Tingting Liu, Chun‐Yu Qiu, Wang‐Ping Hu   +7 more
openalex   +1 more source

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source