Results 121 to 130 of about 303,232 (214)

Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice

Journal of Integrative Neuroscience
Background: Neuroinflammation serves as a pivotal driver of pathology in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) – the widely used animal model of MS.
Suping Qin, Jingjing Guo, Bohui Yuan, Xuejiao Zhang, Shuowei Wang, Yi Ding, Tianxin Zhang, Xiaotian Wang, Dexu Sun, Feng Zhou, Xiaomei Liu   +10 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes

, 2013
In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 ...
CIPRIANI, RAFFAELA, LIMATOLA, Cristina, CHECE, Giuseppina, LAURO, CLOTILDE, PONZETTA, ANDREA, DI ANGELANTONIO, SILVIA, RAGOZZINO, Davide Antonio, CATALANO, Myriam, Ragozzino, Davide   +8 more
core   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson\u27s disease.

, 2018
Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological ...
Dawson, Ted M, Ko, Han Seok, Dawson, Valina L, Lee, Seulki, Kim, Nayoung Alice, Kang, Sung-Ung, Lee, Saebom, Kim, Sangjune, Park, Hyejin, Mari, Zoltan, Brahmachari, Saurav, Yun, Seung Pil, Park, Yong Joo, Kim, SangMin, Lee, Sang Hun, Lee, Yunjong, An, Daniel, Lee, Kang Choon, Liddelow, Shane A, Mao, Xiaobo, Roschke, Viktor V, Lee, Jun Hee, Park, Jong-Sung, Barres, Ben A, Karuppagounder, Senthilkumar S, Kam, Tae-In, Oh, Yumin, Kumar, Manoj, Kim, Donghoon, Oh, Nayeon, Kwon, Seung-Hwan, Na, Dong Hee, Panicker, Nikhil   +32 more
core   +1 more source

3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes

Ischemic stroke is the most common cerebrovascular disease and the leading cause of permanent disability worldwide. Recent studies have shown that stroke development and prognosis are closely related to abnormal tryptophan metabolism.
Qun Wang, Guang Shi, Tie‐Shan Tang, Lu‐Lu Yu, Wei Shan, Jian‐Ping Wu, Jing‐Yu Sun, An‐Chen Guo, Xiang‐Jian Zhang, Jun‐Min Chen   +9 more
core   +1 more source

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

Brain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran, Iban Aldecoa, Arlène Sindikubwabo, Núria Vidal, Rafael Blesa, Mercè Martínez‐Corral, Carlos Nos, Verónica Santiago, Andrea González, Álex Iranzo, Christopher J. Nowinski, Ann C. McKee, Raquel Sánchez Valle, Laura Molina‐Porcel   +13 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source