Results 131 to 140 of about 303,232 (214)

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

High-fat diet and chronic restraint stress exacerbate anxiety-depressive behaviors via astrocytic A1 phenotype transformation

Scientific Reports
Obesity and depression are likely to co-occur. However, there are few reports on the relationship between obesity and depression. We aimed to investigate the effect of high-fat diet combined with chronic restraint stress on depressive-like behaviors ...
Ran Ding, Linyin Gao, Xindi Wang, Jinxia Yang, Xuemei Han, Shuailong Fei, Jian Wang, Xiujun Zhang, Haitao Wang, Xueliang Shang, Lei Wu   +10 more
doaj   +1 more source

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell, Travis D. Gibbons, Connor A. Howe, Jack S. Talbot, Elliott J. Jenkins, L. Madden Brewster, Justin A. Monteleone, Jay M. J. R. Carr, Andrew R. Steele, Michael Stembridge, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis

Glia, Volume 74, Issue 12, December 2026.
Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau, Nicolas Diotel, Sepand Rastegar   +2 more
wiley   +1 more source

Stage-Dependent Function of Astrocytes in Alzheimer’s Disease: A Review

Neuroscience Insights
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), astrogliosis, loss of neurons, and cognitive decline.
Helya Bolouki Azari, Parvin Babaei, Mobina Taghva Nakhjiri   +2 more
doaj   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source

Investigation of Neuropeptide Y as a metabolic marker and its effects on adipose vasculature and brainstem astrocytes [PDF]

, 2015
Subsets of morbidly obese patients do not appear to exhibit the expected comorbidities, as well as the fact that heightened sympathetic nervous system (SNS) activity has been known to affect metabolism.
Casale, C
core  

Application and Research Progress of Nucleic Acid‐Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
This review summarizes recent advances in NADDS for treating ICH, highlighting the advantages and applications of key delivery technologies including lipid nanoparticles, exosomes, and DNA nanostructures. ABSTRACT Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective ...
Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu   +4 more
wiley   +1 more source

Acute trazodone treatment ameliorates behavioral abnormalities and improves subsequent short‐term memory in a lipopolysaccharide‐induced mouse model of acute brain dysfunction

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Aim Systemic inflammation‐associated acute brain dysfunction, typified by delirium, is linked to later cognitive impairment. Although trazodone is used clinically for delirium‐related symptoms, its effects on subsequent cognition remain unclear.
Hideki Matsuoka, Leo Gotoh, Hikaru Hori
wiley   +1 more source