Results 101 to 110 of about 303,232 (214)

Expression and modulation of an NADPH oxidase in mammalian astrocytes [PDF]

, 2005
Amyloid β peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin].
Abramov, A.Y., Wientjes, F., Duchen, M.R., Jacobson, J., Canevari, L., Hothersall, J.   +5 more
core  

Animal models for investigating post‐stroke cognitive impairment: A neurovascular trafficking perspective

Animal Models and Experimental Medicine, EarlyView.
Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley   +1 more source

Functional synapses between cells.

, 2020
A. Synapses between neurons (A1/N4); B. Synapses between neurons and astrocytes (A1/N4); C. No synapses in A4/N1 group. D. 3D co-culture with synapses (A1/N4). Red: Synaptophysin for synapses, green: β-tubulin III for neurons, white: GFAP for astrocytes,
Teal Russell (5844170), Youngmi Koo (1667794), Yeoheung Yun (1667800), Elaine Gay (3864511), Yan Li (23143), Lumei Liu (1655467)   +5 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

TNF-α/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice

Cell Death Discovery
Neuroinflammation is considered to be a significant mechanism contributing to depression. Several studies have reported that A1 astrocytes were highly prevalent in human neuroinflammatory and neurodegenerative diseases.
Mengjiao Gao, Yu Song, Yaqi Liu, Yuqing Miao, Yanwu Guo, Huihui Chai   +5 more
doaj   +1 more source

Exploring A1 activation and miR-155 modulation in ALS spinal cord astrocytes [PDF]

, 2018
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, characterized by motor neurons (MN) loss in the brain and spinal cord (SC).
Sequeira, Catarina Antunes
core  

Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine [PDF]

, 2015
This work was funded by the Wellcome Trust Institutional Strategic Support Fund for University of St. Andrews.Despite considerable evidence that glia can release modulators to influence the excitability of neighbouring neurons, the importance of ...
Miles, Gareth B., David Acton, Acton David, Miles Gareth B., Acton, David, Gareth B Miles, Miles, Gareth B.; id_orcid   +6 more
core   +2 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.

, 2012
Nuc1 is a spontaneous rat mutant resulting from a mutation in the Cryba1 gene, coding for βA3/A1-crystallin. Our earlier studies with Nuc1 provided novel evidence that astrocytes, which express βA3/A1-crystallin, have a pivotal role in retinal remodeling.
Patek, Bonnie, DO, Sinha, Debasish, Valapala, Mallika, Lutty, Gerard A, Zhang, Cheng, Zigler, J Samuel, Yang, Fang, Wawrousek, Eric F, Bhutto, Imran, Stark, Walter J, Hose, Stacey, Cano, Marisol   +11 more
core   +1 more source

Activation and polarization of striatal microglia and astrocytes are involved in bradykinesia and allodynia in early-stage parkinsonian mice

Fundamental Research
In addition to the cardinal motor symptoms, pain is a major non-motor symptom of Parkinson's disease (PD). Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in PD.
Xue Zhang, Zi-Lin Shen, Ya-Wei Ji, Cui Yin, Cheng Xiao, Chunyi Zhou   +5 more
doaj   +1 more source