Results 91 to 100 of about 303,232 (214)

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Endothelial PAI-1 Drives Lead-Induced Cerebral Amyloid Angiopathy via Activation of C3⁺ Decorin⁺ A1-like Astrocytes

Biology
Environmental lead (Pb) exposure remains a significant public health concern, and its association with cerebrovascular injury and Alzheimer’s disease (AD) is increasingly recognized.
Huiying Gu, Cloria Luo, Yansheng Du
doaj   +1 more source

Adenosine A1 receptor activation preferentially protects cultured cerebellar neurons versus astrocytes against hypoxia-induced death

Administration of adenosine A1 receptor agonists in vivo is neuroprotective in various stroke models. Experiments using either mixed cultures of neurons and astrocytes or brain slices, in which several cell types are present, have demonstrated that ...

core   +1 more source

Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes. [PDF]

, 2012
Methylmercury (MeHg) is a well known environmental pollutant that induces serious neuronal damage. Although MeHg readily crosses the blood-brain barrier, and should affect both neurons and glial cells, how it affects glia or neuron-to-glia interactions ...
Yosuke Morizawa (384211), Kayoko Fujishita, Keisuke Shibata (209105), Keisuke Shibata, Yoshio Imura, Schuichi Koizumi (209121), Yosuke Morizawa, Yoshio Imura (384210), Schuichi Koizumi, Youichi Shinozaki (209112), Yusuke Noguchi, Youichi Shinozaki, Christian Gachet, Christian Gachet (82299), Yusuke Noguchi (384209), Kayoko Fujishita (209109), Shibata Keisuke, Morizawa, Yosuke, Fujishita Kayoko, Shinozaki, Youichi, Koizumi, Schuichi, Imura, Yoshio, Shinozaki Youichi, Koizumi Schuichi, Gachet Christian, Morizawa Yosuke, Noguchi, Yusuke, Fujishita, Kayoko, Imura Yoshio, Shibata, Keisuke, Gachet, Christian, Noguchi Yusuke   +31 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Inflammatory Microglia Signals Drive A1-Like Polarization of Astrocytes Even in the Presence of HIV-1 Tat.

In the context of neurodegeneration, activated microglia facilitate inflammation via secretion of TNF-α, IL-1α, and C1q. Astrocytes exposed to this signaling array polarize to a reactive inflammatory phenotype, termed A1 or A1-like.
Barnett, R Jordan, De Souza, Diehl R, Yeakle, Kyle, Dampier, Will, Nonnemacher, Michael R, Mell, Joshua Chang, Lawrence, Jill M, Sen, Bhaswati, Ahmed, Azad, Wigdahl, Brian, Schardien, Kayla, Bouchard, Michael   +11 more
core   +1 more source

Golexanolone affords sustained microglia and astrocytes activation improvement in a rat model of Parkinson’s disease

Frontiers in Immunology
IntroductionGolexanolone improves motor and non-motor alterations in the unilateral 6-OHDA rat model of PD. We hypothesized that a key mechanism by which golexanolone induces these beneficial effects is by reducing microglia activation, thus reducing pro-
Gergana Mincheva, Maria A. Pedrosa, Mar Martínez-García Vázquez, Lola Vazquez, Thomas P. Blackburn, Magnus Doverskog, Marta Llansola, Vicente Felipo   +7 more
doaj   +1 more source

TGFβ3 is Neuroprotective and Alleviates the Neurotoxic Response Induced by Aligned Poly-L-lactic Acid Fibers on Naïve and Activated Primary Astrocytes

, 2020
Following spinal cord injury, astrocytes at the site of injury become reactive and exhibit a neurotoxic (A1) phenotype, which leads to neuronal death. In addition, the glial scar, which is composed of reactive astrocytes, acts as a chemical and physical ...
Gilbert, Ryan J., Popovich, Phillip G., Ziemba, Alexis M., Gottipati, Manoj K., D\u27Amato, Anthony R.   +4 more
core   +1 more source

Genetic Variants of Na+,K+‐ATPase Associated With Neurological Disorders: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Neurological disorders encompass a wide range of severe symptoms and manifestations, many of which are associated with genetic variants that affect ionic homeostasis. Na+,K+‐ATPase, a transmembrane enzyme responsible for maintaining electrochemical gradients in cells, plays a crucial role in neuronal excitability and brain function.
Giovana Kummer da Rosa, Leandro Rodrigo Ribeiro, Jéssica Lorena Bariviera, Mauro Schneider Oliveira   +3 more
wiley   +1 more source

A1 adenosine receptor evoked Ca2+ signals in astrocytes

Current Directions in Biomedical Engineering
In addition to neurons, glial cells make up the nervous system. These glial cells are divided into macroglial cells - including astrocytes - and microglial cells.
Kienleitner Filip, Lenk Kerstin
doaj   +1 more source