Results 81 to 90 of about 303,232 (214)

Paeoniflorin ameliorates Parkinson’s disease by promoting autophagy to inhibit A1 phenotype astrocyte activation

Frontiers in Pharmacology
ObjectiveParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Autophagy dysfunction and astrocyte activation are considered important factors contributing to dopaminergic ...
Yijiao Long, Yijiao Long, Lihui Wang, Lihui Wang, Jun Yin, Baohua Hou, Baohua Hou, Baohua Hou   +7 more
doaj   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway

Journal of Neuroinflammation
Neuroinflammation following subarachnoid hemorrhage (SAH) plays a critical role in multiple pathological pathways and poor prognosis. Several studies have indicated that resting astrocytes can polarize into at least two distinct phenotypes following SAH,
Yu Wu, Boyang Wei, Lei Jin, Longxiang Li, Zeyu Yang, Can Li, Jiaming Zhou, Wenzhi Gong, Xin Feng, Shenquan Guo, Wenping Cheng, Ran Li, Shuyin Liang, Shixing Su, Fa Jin, Xin Zhang, Yanchao Liu, Chuanzhi Duan, Xifeng Li, Wenchao Liu   +19 more
doaj   +1 more source

Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats

Journal of Inflammation Research, 2021
Shuqi Jiang,1,* Huifang Wang,1,2,* Qiuping Zhou,1,3 Qian Li,1,2 Nan Liu,1,3 Zhenggong Li,1 Chunbo Chen,1 Yiyu Deng1,2 1Department of Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou,
Jiang S, Wang H, Zhou Q, Li Q, Liu N, Li Z, Chen C, Deng Y   +7 more
doaj  

Additional file 16 of Transcriptomic profiling of microglia and astrocytes throughout aging

, 2020
Additional file 16. Heatmaps comparing the mean expression of Il1a/TNF in microglia samples and pan-reactive/A1-specific genes in astrocyte samples. A.
Nana Ma (466985), Jie Pan (187977), Wei Zhang (405), Jun Wan (126294), Bo Yu (241082)   +4 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Corrigendum: Induced expression of kir6.2 in A1 astrocytes propagates inflammatory neurodegeneration via Drp1-dependent mitochondrial fission. [PDF]

Front Pharmacol, 2023
Song N, Zhu H, Xu R, Liu J, Fang Y, Zhang J, Ding J, Hu G, Lu M.   +8 more
europepmc   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

IL-17A Mediates Demyelination by Activating A1 Astrocytes via SOCS3 During Angiostrongylus cantonensis Infection. [PDF]

Front Immunol, 2022
Zhou Z, Lin T, Liu Z, Ding Q, Ma Z, Li W, Xie F, Lan Y, Feng Y.   +8 more
europepmc   +1 more source