Molecular Mechanisms of Secreting Vesicle Biogenesis and Secretion in Chronic Degenerative Diseases [PDF]
, 2012 Regulated trafficking and secretion of insulin by the β cell of the endocrine pancreas is critical to maintain our body energy homeostasis. Disruption of these processes typically leads to hyperglycemia and the complications of diabetes.
Qiao, Xinxian
core
Dual-topology insertion of a dual-topology membrane protein. [PDF]
, 2015 Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear.
Bowie, James U +2 more
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Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. [PDF]
Nat Struct Mol Biol, 2020 Lopez KE +8 more
europepmc +1 more source
Insight into the RssB-Mediated Recognition and Delivery of σs to the AAA+ Protease, ClpXP. [PDF]
Biomolecules, 2020 Micevski D +6 more
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Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase [PDF]
, 1992 The ars operon of the conjugative R-factor R773 encodes an oxyanion pump that catalyzes extrusion of arsenicals from cells of Escherichia coli. The oxyanion translocation ATPase is composed of two polypeptides, the catalytic ArsA protein and the ...
Rosen, Barry P. +2 more
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Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP. [PDF]
Commun Biol, 2020 Strack PR +11 more
europepmc +1 more source
A Membrane-Bound Transcription Factor is Proteolytically Regulated by the AAA+ Protease FtsH in Staphylococcus aureus. [PDF]
J Bacteriol, 2020 Yeo WS +9 more
europepmc +1 more source
Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation. [PDF]
J Cell Mol Med, 2020 Lee YJ, Kim GH, Park SI, Lim JH.
europepmc +1 more source
Functional analysis of mammalian m-AAA proteases
, 2008 The m-AAA protease, an ATP-dependent proteolytic complex in the inner mitochondrial membrane, controls mitochondrial protein quality and, acting as a processing enzyme, regulates mitochondrial protein synthesis in yeast. Mammalian m-AAA proteases assemble into several isoenzymes with variable subunit composition.
openaire +1 more source
Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease. [PDF]
EMBO J, 2020 Began J +13 more
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