Results 51 to 60 of about 63,350 (232)
Analysis of the molecular mobility of collagen and elastin in safe, atheromatous and aneurysmal aortas [PDF]
, 2012 Aim of the study : In this study, we propose to use a thermal technique, Differential Scanning Calorimetry (DSC) to follow the evolution of elastin and collagen in safe and pathological cardiovascular tissues.
Dandurand, Jany +7 more
core +2 more sources
Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells.
PLoS ONE, 2011 Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma. Although a majority of studies to date have concentrated on reactive gliosis in the optic nerve head, very few studies have been initiated to investigate the
Bhagyalaxmi S Ganesh, Shravan K Chintala
doaj +1 more source
Artery Research, 2020 In contrast to abdominal aortic aneurysm (AAA), aneurysms of the thoracic ascending aorta (TAA) are not associated with a mural thrombus. Mechanistic understanding of the involvement of vascular smooth muscle cells (VSMCs) in thrombus formation is ...
Melusine Didelot +4 more
doaj +1 more source
Electron Cryomicroscopy Structure of a Membrane-anchored Mitochondrial AAA Protease [PDF]
Journal of Biological Chemistry, 2011 FtsH-related AAA proteases are conserved membrane-anchored, ATP-dependent molecular machines, which mediate the processing and turnover of soluble and membrane-embedded proteins in eubacteria, mitochondria, and chloroplasts. Homo- and hetero-oligomeric proteolytic complexes exist, which are composed of homologous subunits harboring an ATPase domain of ...
Lee, S. +5 more
openaire +3 more sources
Multistep substrate binding and engagement by the AAA+ ClpXP protease [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance AAA+ proteases play key regulatory and quality control roles in all domains of life. These destructive enzymes recognize damaged, unneeded, or regulatory proteins via specific degrons and unfold them prior to processive degradation. Here, we show that Escherichia coli
Reuben A. Saunders +3 more
openaire +2 more sources
Cells, 2018 The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different compartments of the organelle or directly produced in the mitochondrial matrix.
Braulio Vargas Möller-Hergt +3 more
doaj +1 more source
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. [PDF]
, 2012 The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)-0, -I, -II, and -III ...
Chen, Buxin +7 more
core +3 more sources
Bio-Protocol, 2020 Skd3 (encoded by human CLPB) is a mitochondrial AAA+ protein comprised of an N-terminal ankyrin-repeat domain and a C-terminal HCLR-clade nucleotide-binding domain. The function of Skd3 has long remained unknown due to challenges in purifying the protein
Ryan Cupo, James Shorter
doaj +1 more source
Fluorescence Methods Applied to the Description of Urea-Dependent YME1L Protease Unfolding
Biomolecules, 2020 ATP-dependent proteases are ubiquitous across all kingdoms of life and are critical to the maintenance of intracellular protein quality control. The enzymatic function of these enzymes requires structural stability under conditions that may drive ...
Sydney Moore +4 more
doaj +1 more source
Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]
, 2003 A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Assfalg-Machleidt, Irmgard +5 more
core +1 more source