Results 181 to 190 of about 144,727 (384)

Adeno-Associated Virus (AAV) Gene Therapy pada Hemofilia: A Systematic Review

Majalah Kedokteran Andalas
Hemofilia A (HA) dan Hemofilia B (HB) adalah kelainan perdarahan terkait kromosom X yang disebabkan oleh defisiensi faktor koagulasi Faktor VIII (FVIII) atau Faktor IX (FIX).
Winda Angriani, Fitrah Afdhal
doaj   +1 more source

Recombinant AAV-Mediated Delivery of a Tet-Inducible Reporter Gene to the Rat Retina [PDF]

, 2001
Laura H.McGee Sanftner, Katherine G. Rendahl, Dulce Quiroz, Mazie Coyne, Martha Ladner, William C. Manning, John G. Flannery   +6 more
openalex   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Development of recombinant adeno-associated virus empty capsids as a reference standard for quality control of gene therapy products

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The development of adeno-associated virus (AAV)-based gene therapy products in Russia requires establishing reference standards, which are used throughout the pharmaceutical development cycle, and monitoring their stability during the ...
A. V. Tumaev, D. Yu. Voloshin, E. S. Berdinskikh, E. L. Sakhibgaraeva, E. V. Golovin, E. N. Subcheva, O. O. Vasileva, A. A. Galieva, A. A. Chuvashov, E. S. Novikova, A. V. Karabelsky   +10 more
doaj   +1 more source

Complementation of Adeno-Associated Satellite Virus (AAV) by Temperature-Sensitive Mutants of Adenovirus Type 31

, 1977
Heather D. Mayor, Sébastien Carrier, Liane E. Jordan   +2 more
openalex   +1 more source

AAV-Mediated Delivery of Ciliary Neurotrophic Factor Prolongs Photoreceptor Survival in the Rhodopsin Knockout Mouse [PDF]

, 2001
Fong-Qi Liang, Nadine S. Dejneka, Daniel R. Cohen, Natalia V. Krasnoperova, Janis Lem, Albert M. Maguire, Lorita Dudus, Krishna J. Fisher, Jean Bennett   +8 more
openalex   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis

Frontiers in Immunology
ObjectiveDespite recent advances, the pathophysiological mechanisms underlying anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) remain incompletely understood, and comparative proteomic analyses of AAV subtypes are lacking.
Erik Hellbacher, Erik Hellbacher, Vincent van Hoef, Alina Johansson, Ann Knight, Ann Knight, Iva Gunnarsson, Iva Gunnarsson, Annette Bruchfeld, Annette Bruchfeld, Per Eriksson, Sophie Ohlsson, Solbritt Rantapää-Dahlqvist, Johanna Dahlqvist, Johanna Dahlqvist   +14 more
doaj   +1 more source

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

Nature Network Boston, 2020
C. Leborgne, Elena Barbon, Jeffrey M. Alexander, H. Hanby, S. Delignat, D. Cohen, F. Collaud, Saghana Muraleetharan, Dan Lupo, Joseph Silverberg, Karen Huang, Laetitia van Wittengerghe, Béatrice Marolleau, Adeline Miranda, Anna Fabiano, Victoria Daventure, Heena Beck, X. Anguela, G. Ronzitti, S. Armour, S. Lacroix-Desmazes, F. Mingozzi   +21 more
semanticscholar   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source