Results 181 to 190 of about 131,610 (332)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice [PDF]

, 2015
Ram Lakhan, David J. Baylink, K.‐H. William Lau, Xiaolei Tang, Matilda H.‐C. Sheng, Charles H. Rundle, Xuezhong Qin   +6 more
openalex   +1 more source

Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency [PDF]

, 2023
Zengpeng Han, Nengsong Luo, Fei Wang, Yuxiang Cai, Xin Yang, Weiwei Feng, Zhenxiang Zhu, Jie Wang, Yang Wu, Chaohui Ye, Kunzhang Lin, Fuqiang Xu   +11 more
openalex   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Analyses of the Effects of Wild-Type TDP-43 Overexpression in Oxytocin Neurons in Mice. [PDF]

Neuropathol Appl Neurobiol
Bergh S, Simonsson O, Petersén Å.
europepmc   +1 more source

241. A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys [PDF]

, 2006
John Forsayeth, Jamie L. Eberling, Laura Sanftner, Zhu Zhen, Philip Pivirotto, John R. Bringas, Janet Cunningham, Krystof S. Bankiewicz   +7 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes. [PDF]

Synth Syst Biotechnol
Ren H, Nie J, Song Z, Mo W, Yang Y, Bai Z.   +5 more
europepmc   +1 more source

AAV-Mediated Delivery of Ribonucleotide Reductase and Microdystrophin Rescues Function in Dystrophic Mice [PDF]

, 2018
Jason D. Murray, Guy L. Odom, Sigurast Olafsson, Stephen D. Hauschka, Jeffrey S. Chamberlain, Farid Moussavi‐Harami, Michael Regnier   +6 more
openalex   +1 more source

AAV Craniotomy v1

This protocol is for injection of AAV into a mouse brain using a stereotactic frame and Hamilton syringe.
Santiago Unda, Roberta Marongiu, Mihaela Stavarache, Michael G. Kaplitt   +3 more
openaire   +1 more source