Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma
International Immunopharmacology, 2022 The treatment of relapse or refractory multiple myeloma (RRMM) is still a big challenge in clinic. Recently, several clinical trials indicated that the XPO1 inhibitor, selinexor could significantly improve the remission rate in MM patients. However, the heterogeneous genetic background greatly influenced the efficiency of selinexor among MM.
Fang, Hu +7 more
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Advances in Urate Excretion and Urate Transporters in Hyperuricemia [PDF]
Zhongguo quanke yixue, 2023 Hyperuricemia is a heterogeneous disease caused by dysregulation of the homeostasis of urate production and excretion, which leads to the elevation of blood uric acid beyond the normal range.
XIN Jiadong, ZHOU Jiabao, WU Zhiyuan, ZHANG Xuming, GAO Jiandong
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Blockade of multidrug resistance associated proteins aggravates acute pancreatitis and blunts atrial natriuretic factor beneficial effect in rats: Role of MRP4/ABCC4 [PDF]
, 2015 We previously reported that atrial natriuretic factor (ANF) stimulates secretin-evoked cAMP efflux through multidrug resistance-associated protein 4 (MRP4) in the exocrine pancreas.
Bianciotti, Liliana Graciela +6 more
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Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]
Journal of Medical Biochemistry, 2018 Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran +10 more
doaj
ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma [PDF]
Frontiers in Oncology, 2012 Resistance to cytotoxic drugs is thought to be a major cause of treatment failure in childhood neuroblastoma, and members of the ATP-binding cassette (ABC) transporter superfamily may contribute to this phenomenon by active efflux of chemotherapeutic agents from cancer cells.
Huynh, Tony +3 more
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Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci [PDF]
, 2016 Background: Ulcerative colitis (UC), a complex polygenic disorder, is one of the main subphenotypes of inflammatory bowel disease. A comprehensive dissection of the genetic etiology of UC needs to assess the contribution of rare genetic variants ...
Andre Franke +11 more
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MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease
Pharmacological Research, 2016 This review focuses on multidrug resistance protein 4 (MRP4 or ABCC4) that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions. In vascular system, recent data provide evidence that inhibition of MRP4 prevents human coronary artery smooth muscle cell proliferation in vitro and in vivo,
Tiphaine, Belleville-Rolland +6 more
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ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population [PDF]
Disease Markers, 2018 A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations. However, significant differences exist among ethnic populations in European and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility ...
Di Che +8 more
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Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness [PDF]
Scientific Reports, 2020 AbstractRecent findings show that MRP4 is critical for pancreatic ductal adenocarcinoma (PDAC) cell proliferation. Nevertheless, the significance of MRP4 protein levels and function in PDAC progression is still unclear. The aim of this study was to determine the role of MRP4 in PDAC tumor aggressiveness. Bioinformatic studies revealed that PDAC samples
Ana Sahores +10 more
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Frequent down-regulation of ABC transporter genes in prostate cancer [PDF]
, 2015 Background: ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes.
Deividas Razanauskas +5 more
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