Results 191 to 200 of about 26,096 (220)
Some of the next articles are maybe not open access.
Cancer Letters, 2009
Sunitinib is an ATP-competitive multi-targeted tyrosine kinase inhibitor. In this study, we evaluated the possible interaction of sunitinib with P-glycoprotein (P-gp, ABCB1), multidrug resistance protein 1 (MRP1, ABCC1), breast cancer resistance protein (BCRP, ABCG2) and lung-resistance protein (LRP) in vitro.
Liwu Fu, Amit K Tiwari, Zhe-Sheng Chen
exaly +3 more sources
Sunitinib is an ATP-competitive multi-targeted tyrosine kinase inhibitor. In this study, we evaluated the possible interaction of sunitinib with P-glycoprotein (P-gp, ABCB1), multidrug resistance protein 1 (MRP1, ABCC1), breast cancer resistance protein (BCRP, ABCG2) and lung-resistance protein (LRP) in vitro.
Liwu Fu, Amit K Tiwari, Zhe-Sheng Chen
exaly +3 more sources
Journal of Medicinal Chemistry, 2020
In the search for highly effective modulators addressing ABCG2-mediated MDR, 23 pyrimidines were synthesized and biologically assessed. Seven derivatives with (a) nitrogen- and/or halogen-containing residue(s) had extraordinary potencies against ABCG2 (IC50 < 150 nM). The compounds competitively inhibited ABCG2-mediated Hoechst 33342 transport but were
Katja Silbermann +6 more
openaire +2 more sources
In the search for highly effective modulators addressing ABCG2-mediated MDR, 23 pyrimidines were synthesized and biologically assessed. Seven derivatives with (a) nitrogen- and/or halogen-containing residue(s) had extraordinary potencies against ABCG2 (IC50 < 150 nM). The compounds competitively inhibited ABCG2-mediated Hoechst 33342 transport but were
Katja Silbermann +6 more
openaire +2 more sources
ABCG2/BCRP: Specific and Nonspecific Modulators
Medicinal Research Reviews, 2016AbstractMultidrug resistance (MDR) in cancer cells is the development of resistance to a variety of structurally and functionally nonrelated anticancer drugs. This phenomenon has become a major obstacle to cancer chemotherapy seriously affecting the clinical outcome.
Diana, Peña-Solórzano +4 more
openaire +2 more sources
Comparison of chemotherapeutic drug resistance in cells transfected with canine
AbstractABCG2(ATP binding cassette subfamily G, member 2) mediates resistance to a variety of cytotoxic agents. Although humanABCG2is well characterized, the function of canineABCG2has not been studied previously. FelineABCG2has an amino acid substitution in the adenosine triphosphate‐binding domain that decreases its transport capacity relative to ...
R S, Lewis +5 more
openaire +2 more sources
Drug Metabolism and Disposition, 2014
Lignans are phytoestrogens that are metabolized by the gut microbiota to enterodiol and enterolactone, the main biologically active enterolignans. Substantial interindividual variation in plasma concentration and urinary excretion of enterolignans has been reported, this being determined, at least in part, by the intake of lignan precursors, the gut ...
Verónica, Miguel +6 more
openaire +2 more sources
Lignans are phytoestrogens that are metabolized by the gut microbiota to enterodiol and enterolactone, the main biologically active enterolignans. Substantial interindividual variation in plasma concentration and urinary excretion of enterolignans has been reported, this being determined, at least in part, by the intake of lignan precursors, the gut ...
Verónica, Miguel +6 more
openaire +2 more sources
ABCG2 as a therapeutic target candidate for gout
Expert Opinion on Therapeutic Targets, 2017Hyperuricemia (chronically elevated serum uric acid) is the main pathology underlying the development of gout, the most common inflammatory arthropathy. Management of these conditions therefore relies on controlling serum uric acid levels. ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a well-studied urate transporter ...
Kyoko Fujita, Kimiyoshi Ichida
openaire +2 more sources
Trials and Tribulations in the Expression and Purification of ABCG2
2016ABC (ATP binding cassette) transporters are a diverse superfamily of membrane proteins, which couple the transport of substrate with the hydrolysis of ATP. ABCG2 (ATP binding cassette G2, also known as Breast Cancer Resistance Protein (BCRP), is a well-known multidrug efflux pump that transports a wide range of structurally unrelated chemotherapeutic ...
openaire +2 more sources
Cryo-EM Structures of a Human ABCG2 Mutant Trapped in ATP-Bound and Substrate-Bound States
Nature, 2018Henning Stahlberg +2 more
exaly
Single Nucleotide Polymorphisms Modify the Transporter Activity of ABCG2
Cancer Chemotherapy and Pharmacology, 2005Rob Robey +2 more
exaly