Results 1 to 10 of about 235,032 (267)

Clinical Outcome in Patients With Intracerebral Hemorrhage Stratified by Type of Antithrombotic Therapy

Frontiers in Neurology, 2021
Background: Antithrombotic therapy influences clinical outcome after spontaneous intracerebral hemorrhage (ICH). However, evidence on the effect of different antithrombotic therapies on outcome and a comparison between different therapies is scarce ...
Merih Irem Baharoglu, Jonathan M. Coutinho, Henk A. Marquering, Henk A. Marquering, Charles B. Majoie, Yvo B. Roos   +5 more
doaj   +1 more source

An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

Genome Medicine, 2021
Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract ...
Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna   +12 more
doaj   +1 more source

Routine Echocardiography and Artificial Intelligence Solutions

Frontiers in Cardiovascular Medicine, 2021
Introduction: Echocardiography is widely used because of its portability, high temporal resolution, absence of radiation, and due to the low-costs. Over the past years, echocardiography has been recommended by the European Society of Cardiology in most ...
Mark J. Schuuring, Ivana Išgum, Ivana Išgum, Ivana Išgum, Bernard Cosyns, Steven A. J. Chamuleau, Steven A. J. Chamuleau, Berto J. Bouma   +7 more
doaj   +1 more source

Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review

Clinical and Translational Discovery, 2022
Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for animal‐free ...
Giulia Moreni, Ikrame Aknouch, Morris Ras, Lieke Brouwer, René Spijker, Carlemi Calitz, Koert J. Stittelaar, Adithya Sridhar, Katja C. Wolthers, Dasja Pajkrt   +9 more
doaj   +1 more source

Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

Critical Care, 2022
Background Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibiotic with broad immunomodulatory ...
Tom D. Y. Reijnders, Hessel Peters-Sengers, Lonneke A. van Vught, Fabrice Uhel, Marc J. M. Bonten, Olaf L. Cremer, Marcus J. Schultz, Martijn M. Stuiver, Tom van der Poll, the MARS consortium   +9 more
doaj   +1 more source

Early Postnatal Cardiac Stress Does Not Influence Ventricular Cardiomyocyte Cell-Cycle Withdrawal

Journal of Cardiovascular Development and Disease, 2021
Congenital heart disease (CHD) is the most common birth defect. After birth, patients with CHD may suffer from cardiac stress resulting from abnormal loading conditions.
Marie Günthel, Karel van Duijvenboden, Jorn Jeremiasse, Maurice J. B. van den Hoff, Vincent M. Christoffels   +4 more
doaj   +1 more source

Advertising by Academic Medical Centers [PDF]

Archives of Internal Medicine, 2005
Many academic medical centers have increased their use of advertising to attract patients. While the content of direct-to-consumer pharmaceutical advertisements (ads) has been studied, to our knowledge, advertising by academic medical centers has not. We aimed to characterize advertising by the nation's top academic medical centers.We contacted all 17 ...
Robin J, Larson, Lisa M, Schwartz, Steven, Woloshin, H Gilbert, Welch   +3 more
openaire   +2 more sources

The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis

Critical Care, 2020
Background Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical splicing, characterized by the ...
Hina N. Khan, Xanthe Brands, Simona Aufiero, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Tjitske S. R. van Engelen, Bastiaan W. Haak, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Tom van der Poll, Brendon P. Scicluna   +12 more
doaj   +1 more source

Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study

Journal of Eating Disorders, 2023
Background Anorexia nervosa (AN) is a severe and life-threatening psychiatric disorder. Initial studies on deep brain stimulation (DBS) in severe, treatment-refractory AN have shown clinical effects.
M. S. Oudijn, J. T. W. Linders, A. Lok, P. R. Schuurman, P. van den Munckhof, A. A. van Elburg, G. A. van Wingen, R. J. T. Mocking, D. Denys   +8 more
doaj   +1 more source

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

Frontiers in Immunology, 2021
Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin, Brendon P. Scicluna, Brendon P. Scicluna, Tom van der Poll, Tom van der Poll   +4 more
doaj   +1 more source