Results 61 to 70 of about 354,268 (327)

Social disadvantage accelerates aging

Nature Medicine
Abstract Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases.
Kivimäki, M, Pentti, J, Frank, P, Liu, F, Blake, A, Nyberg, ST, Vahtera, J, Singh-Manoux, A, Wyss-Coray, T, Walker, KA, Partridge, L, Lindbohm, JV   +11 more
openaire   +3 more sources

Age-Specific Acceleration of Cancer [PDF]

Current Biology, 2004
One of the great challenges of cancer research is to explain the epidemiological patterns of cancer incidence based on the molecular processes that lead to uncontrolled cellular proliferation. The epidemiological data demonstrate that the age-specific incidence of many cancers increases in an approximately linear way with age when plotted on a log-log ...
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Some molecular-genetic determinants of premature aging in women

Consilium Medicum
Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be an important factor in this process. Aim.
Elena V. Kudryavtseva, Dinara A. Berezina, Daniil O. Kornilov, Veronika M. Simarzina, Mikhail A. Tryapitsyn, Aleksey A. Bekhter, Vladislav V. Kovalev, Danila L. Zornikov   +7 more
doaj   +1 more source

Accelerated aging for evaluation of vigor in Brachiaria brizantha ‘Xaraés’ seeds

Journal of Seed Science, 2020
: The aim of this study was to adjust the accelerated aging test to evaluate the physiological potential of seed lots of Brachiaria brizantha ‘Xaraés’, represented by four lots.
Ariadne Morbeck Santos Oliveira, Marcela Carlota Nery, Karina Guimarães Ribeiro, Adriana Souza Rocha, Priscila Torres Cunha   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effects of Accelerated Aging and Acid Scarification of Seed Coat with Hydrochloric Acid on Seed Germination Characteristics of Chickpea c.v. Kaka [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2014
To evaluate the effects of accelerated aging and seed coat scarification with Hydrochloric acid (HCl) on seed germination characteristics of chickpea (Cicer arietinum) c.v.
R. Sadrabadi Haghighi
doaj  

Impact of Wetting–Drying Cycles on the Mechanical Properties and Microstructure of Wood Waste–Gypsum Composites [PDF]

, 2019
Large amounts of wood waste are generated each year in the world. In an attempt to identify a good recovery option for those residues, wood waste from construction and demolition works were used as raw materials in gypsum plasters.
Morales Conde, María Jesús, Pedreño-Rojas, M. Alejandro, Pérez Gálvez, Filomena, Rubio de Hita, Paloma   +3 more
core   +1 more source

Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking. [PDF]

, 2020
BackgroundCerebellar atrophy (especially involving the superior-anterior cerebellar vermis) is among the most salient and clinically significant effects of chronic hazardous alcohol consumption on brain structure.
Cootes T, Fregly AR, Harper CG, Sullivan EV, Victor M, Wang X   +5 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source