Results 21 to 30 of about 71,112 (230)

Accessory Genome Dynamics and Structural Variation of <i>Shigella</i> from Persistent Infections. [PDF]

mBio, 2021
Abstract Shigellosis is a diarrhoeal disease caused mainly by Shigella flexneri and Shigella sonnei . Infection from Shigella is thought to be largely self-limiting, with short- to medium- term and serotype ...
Bengtsson RJ, Dallman TJ, Allen H, De Silva PM, Stenhouse G, Pulford CV, Bennett RJ, Jenkins C, Baker KS.   +8 more
europepmc   +8 more sources

Characterization of accessory genes in coronavirus genomes [PDF]

Virology Journal, 2020
Abstract Background: The Covid19 infection is caused by the SARS-CoV-2 virus, a novel member of the coronavirus (CoV) family. CoV genomes code for a ORF1a / ORF1ab polyprotein and four structural proteins widely studied as major drug targets. The genomes also contain a variable number of open reading frames (ORFs) coding for accessory proteins ...
Michel, Christian Jean, Mayer, Claudine, Poch, Olivier, Thompson, Julie   +3 more
openaire   +5 more sources

Core genes can have higher recombination rates than accessory genes within global microbial populations

eLife, 2022
Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg, Mingzhi Lin, Edo Kussell   +2 more
doaj   +1 more source

The Accessory Genome of Pseudomonas aeruginosa [PDF]

Microbiology and Molecular Biology Reviews, 2010
SUMMARY Pseudomonas aeruginosa strains exhibit significant variability in pathogenicity and ecological flexibility. Such interstrain differences reflect the dynamic nature of the P. aeruginosa genome, which is composed of a relatively invariable “core genome” and a highly
Vanderlene L, Kung, Egon A, Ozer, Alan R, Hauser   +2 more
openaire   +2 more sources

CRISPR-Cas System: The Powerful Modulator of Accessory Genomes in Prokaryotes [PDF]

Microbial Physiology, 2021
Being frequently exposed to foreign nucleic acids, bacteria and archaea have developed an ingenious adaptive defense system, called CRISPR-Cas. The system is composed of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) array, together with CRISPR (<i>cas</i>)-associated genes.
Anca, Butiuc-Keul, Anca, Farkas, Rahela, Carpa, Dumitrana, Iordache   +3 more
openaire   +2 more sources

The influence of the accessory genome on bacterial pathogen evolution [PDF]

Mobile Genetic Elements, 2011
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity. Molecular arms-races have been a strong driving force for the evolution of pathogenicity, with pathogens often encoding overlapping or ...
Jackson, Robert W., Vinatzer, Boris, Arnold, Dawn L., Dorus, Steve, Murillo Martínez, Jesús   +4 more
openaire   +5 more sources

Giant Starship Elements Mobilize Accessory Genes in Fungal Genomes [PDF]

Molecular Biology and Evolution, 2021
Abstract Accessory genes are variably present among members of a species and are a reservoir of adaptive functions. In bacteria, differences in gene distributions among individuals largely result from mobile elements that acquire and disperse accessory genes as cargo.
Emile Gluck-Thaler, Timothy Ralston, Zachary Konkel, Cristhian Grabowski Ocampos, Veena Devi Ganeshan, Anne E. Dorrance, Terry L. Niblack, Corlett W. Wood, Jason C. Slot, Horacio D. Lopez-Nicora, Aaron A. Vogan   +10 more
openaire   +3 more sources

Genome compartmentalization predates species divergence in the plant pathogen genus Zymoseptoria

BMC Genomics, 2020
Background Antagonistic co-evolution can drive rapid adaptation in pathogens and shape genome architecture. Comparative genome analyses of several fungal pathogens revealed highly variable genomes, for many species characterized by specific repeat-rich ...
Alice Feurtey, Cécile Lorrain, Daniel Croll, Christoph Eschenbrenner, Michael Freitag, Michael Habig, Janine Haueisen, Mareike Möller, Klaas Schotanus, Eva H. Stukenbrock   +9 more
doaj   +1 more source

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

mBio, 2021
SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins.
Amin Addetia, Nicole A. P. Lieberman, Quynh Phung, Tien-Ying Hsiang, Hong Xie, Pavitra Roychoudhury, Lasata Shrestha, Michelle A. Loprieno, Meei-Li Huang, Michael Gale, Keith R. Jerome, Alexander L. Greninger   +11 more
doaj   +1 more source

AcCNET (Accessory Genome Constellation Network): comparative genomics software for accessory genome analysis using bipartite networks [PDF]

Bioinformatics, 2016
Abstract AcCNET (Accessory genome Constellation Network) is a Perl application that aims to compare accessory genomes of a large number of genomic units, both at qualitative and quantitative levels. Using the proteomes extracted from the analysed genomes, AcCNET creates a bipartite network compatible with standard network analysis ...
Val F. Lanza, Fernando Baquero, Fernando de la Cruz, Teresa M. Coque   +3 more
openaire   +3 more sources