Results 11 to 20 of about 620,051 (294)

The systemic renin-angiotensin system in COVID-19

Scientific Reports, 2022
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound enzyme of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective angiotensin 1–7.
Roman Reindl-Schwaighofer, Sebastian Hödlmoser, Oliver Domenig, Katharina Krenn, Farsad Eskandary, Simon Krenn, Christian Schörgenhofer, Benedikt Rumpf, Mario Karolyi, Marianna T. Traugott, Agnes Abrahamowicz, Viktoria Tinhof, Hannah Mayfurth, Vincent Rathkolb, Sebastian Mußnig, Lukas Schmölz, Roman Ullrich, Andreas Heinzel, Franz König, Christina Binder, Diana Bonderman, Robert Strassl, Elisabeth Puchhammer-Stöckl, Gregor Gorkiewicz, Judith H. Aberle, Bernd Jilma, Christoph Wenisch, Marko Poglitsch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking   +30 more
doaj   +1 more source

The Influence of ACE Insertion/Deletion Gene Polymorphism on the Risk of IgA Nephropathy: A Debatable Topic

Genetics Research, 2021
Background. The connection between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphisms and IgA nephropathy (IgAN) was conflicting. This pooled analysis was performed to explore this issue. Methods.
Fen-Fen Chu, Shi-Kun Yang, Wen-Li Zeng
doaj   +1 more source

Physical Activity and Inhibition of ACE Additively Modulate ACE/ACE-2 Balance in Heart Failure in Mice

Frontiers in Pharmacology, 2021
Angiotensin-converting enzyme inhibition (ACE-I) and physical activity favorably modulate the ACE/ACE-2 balance. However, it is not clear whether physical activity and ACE-I could synergistically modulate ACE/ACE-2 balance in the course of heart failure (
Urszula Tyrankiewicz, Mariola Olkowicz, Piotr Berkowicz, Piotr Berkowicz, Magdalena Jablonska, Ryszard T. Smolenski, Jerzy A. Zoladz, Stefan Chlopicki, Stefan Chlopicki   +8 more
doaj   +1 more source

Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.

PLoS ONE, 2022
BackgroundSickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure (BP), via an ...
Pamela L Brito, Alisson F Dos Santos, Hanan Chweih, Maria E Favero, Erica M F Gotardo, Juliete A F Silva, Flavia C Leonardo, Carla F Franco-Penteado, Mariana G de Oliveira, Wilson A Ferreira, Bruna C Zaidan, Athanase Billis, Giorgio Baldanzi, Denise A Mashima, Edson Antunes, Sara T Olalla Saad, Fernando F Costa, Nicola Conran   +17 more
doaj   +1 more source

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
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Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol

Systematic Reviews, 2018
Background Momordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus.
Emanuel L. Peter, Serawit Deyno, Andrew Mtewa, Félicien Mushagalusa Kasali, Prakash B. Nagendrappa, Duncan Sesaazi, Casim Umba Tolo, Patrick Engeu Ogwang   +7 more
doaj   +1 more source

Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology [PDF]

, 2016
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer’s disease (AD). Angiotensin-
Al Mulhim, Noura S K, Kehoe, Patrick Gavin, Miners, J Scott, Palmer, Laura Elyse, Wong, Steffenny   +4 more
core   +3 more sources

Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex [PDF]

, 2016
Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac ...
Chang, Ching-Pin, Chen, Huei-Sheng Vincent, Cheng, Wei, Feng, Xuhui, Han, Pei, Lin, Chiou-Hong, Quertermous, Thomas, Shang, Ching, Yang, Jin, Zhou, Qiong   +9 more
core   +1 more source

ANTIMICROBIAL AND ANTIVIRAL PROPERTIES OF METAL NANOPARTICLES AND THEIR POTENTIAL USE IN TEXTILES: A REVIEW [PDF]

Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2022
Recent global trends have put an emphasis on the importance of hygiene in all sectors including textiles. Antimicrobial and antiviral finishes are used in textiles to control bacteria, moulds, fungi and viruses on the textile substrate.
MPOFU Nonsikelelo Sheron, MWASIAGI Josphat Igadwa, NGANYI Eric Oyondi, KAMALHA Edwin   +3 more
doaj  

Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction [PDF]

, 2014
Introduction: Disturbance of the uteroplacental circulation (UPC) and the renin-angiotensin system are involved in the pathogenesis of preeclampsia. In women with history of preeclampsia persistently elevated C-reactive protein (CRP) levels have been ...
Hoppe, Berthold, Häupl, Thomas, Kalus, Ulrich, Koscielny, Jürgen, Yürek, Salih, Zimmermann, Mathias   +5 more
core   +1 more source