Results 231 to 240 of about 250,937 (292)

Optimization of Malonyl Coenzyme A Biosensors in a Reconstituted Cell-Free System for Detecting Acetyl-CoA Carboxylase Activity. [PDF]

ACS Synth Biol
Ito S, Nishikawa S, Terasaka N, Fujishima K.   +3 more
europepmc   +1 more source

Ligand binding to a Ni-Fe cluster orchestrates conformational changes of the CO-dehydrogenase-acetyl-CoA synthase complex. [PDF]

Nat Catal
Ruickoldt J, Kreibich J, Bick T, Jeoung JH, Duffus BR, Leimkühler S, Dobbek H, Wendler P.   +7 more
europepmc   +1 more source

HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA. [PDF]

Nat Commun
Bae JE, Jang S, Kim JB, Park NY, Jo DS, Hyung H, Kim P, Kim MS, Ryu HY, Lee HS, Lee DS, Baes M, Ryoo ZY, Cho DH.   +13 more
europepmc   +1 more source

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells. [PDF]

Bio Protoc
Sun Y, Li J, Zhao L, Zhu H.
europepmc   +1 more source

The conversion of acetyl-CoA apocarboxylase into the active holocarboxylase by acetyl-CoA holocarboxylase synthetase

, 1976
openaire   +1 more source

Engineering a Novel Acetyl-CoA Pathway for Efficient Biosynthesis of Acetyl-CoA-Derived Compounds

ACS Synthetic Biology, 2023
Acetyl-CoA is an essential central metabolite in living organisms and a key precursor for various value-added products as well. However, the intracellular availability of acetyl-CoA limits the efficient production of these target products due to complex and strict regulation. Here, we proposed a new acetyl-CoA pathway, relying on two enzymes, threonine
Mengzhen Nie, Jingyu Wang, Kechun Zhang
openaire   +3 more sources

Multi-subunit acetyl-CoA carboxylases

Progress in Lipid Research, 2002
Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins.
John E, Cronan, Grover L, Waldrop
openaire   +3 more sources

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis [PDF]

Molecular Cell, 2022
Acetyl-coenzyme A (acetyl-CoA) plays an important role in metabolism, gene expression, signaling, and other cellular processes via transfer of its acetyl group to proteins and metabolites.
Xueya Wang
exaly   +3 more sources

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Acetyl-CoA metabolism in cancer

Nature Reviews Cancer, 2023
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the tricarboxylic acid cycle and is the essential building block for fatty acid and isoprenoid biosynthesis.
David A. Guertin, Kathryn E. Wellen
openaire   +2 more sources