Results 231 to 240 of about 172,172 (296)

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

<i>Fusobacterium nucleatum</i> exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation. [PDF]

Gut Microbes
Xiang Z, Li X, Wang X, Deng B, He H, Xu M, Wu X, Tan C, Liu Y, Yu B, Zhang J, Dong W.   +11 more
europepmc   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

Genetic identification of acetyl-CoA synthetases involved in acetate activation in Haloferax mediterranei. [PDF]

Appl Environ Microbiol
Mitra R, Xu Y, Lin L, Guo J, Xu T, Zhou M, Guo F, Li H, Xiang H, Han J.   +9 more
europepmc   +1 more source

Acetyl-CoA Carboxylase Inhibitors for Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Pharmaceuticals (Basel)
Hasanatuludhhiyah N, Mustika A, Kalanjati VP, Miftahussurur M, Uemura N.   +4 more
europepmc   +1 more source

SIRT4 Controls Acetyl-CoA Synthesis to Promote Stemness and Invasiveness of Hepatocellular Carcinoma through Deacetylating MCCC2. [PDF]

Int J Biol Sci
Sun T, Xu C, Song Q, Yang X, An G, Sun G, Zhang Z.   +6 more
europepmc   +1 more source

Evolution of the regulatory subunits for the heteromeric acetyl-CoA carboxylase. [PDF]

Philos Trans R Soc Lond B Biol Sci
Conrado AC, Lemes Jorge G, Rao RSP, Xu C, Xu D, Li-Beisson Y, Thelen JJ.   +6 more
europepmc   +1 more source

Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion. [PDF]

J Clin Invest
McDonald-Hyman C, Aguilar EG, Compeer EB, Zaiken MC, Rhee SY, Mohamed FA, Larson JH, Loschi ML, Lees C, Thangavelu G, Sleeth ML, Smith KD, Whangbo JS, Ritz J, Sparwasser TD, O'Connor RS, Crawford PA, Rathmell JC, Kean LS, Zeiser R, Hippen KL, Dustin ML, Blazar BR.   +22 more
europepmc   +1 more source

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Acetyl-CoA metabolism in cancer

Nature Reviews Cancer, 2023
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the tricarboxylic acid cycle and is the essential building block for fatty acid and isoprenoid biosynthesis.
David Guertin, Kathryn E Wellen
exaly   +3 more sources