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Methods to Study Mitochondrial Metabolism and Homeostasis in Fission Yeast
Yeast, EarlyView.
Ferran Gómez‐Armengol +2 more
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. [PDF]
Nguyen PTT +17 more
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Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. [PDF]
Li X +8 more
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Hydrolysis of the acetyl-CoA allosteric activator by Staphylococcus aureus pyruvate carboxylase. [PDF]
Laseke AJ, Lohman JR, St Maurice M.
europepmc +1 more source
Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation. [PDF]
Cossin JR +5 more
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Acetyl-CoA metabolism in cancer
Nature Reviews Cancer, 2023Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the tricarboxylic acid cycle and is the essential building block for fatty acid and isoprenoid biosynthesis.
David A Guertin +2 more
exaly +3 more sources
Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis [PDF]
Acetyl-coenzyme A (acetyl-CoA) plays an important role in metabolism, gene expression, signaling, and other cellular processes via transfer of its acetyl group to proteins and metabolites.
Xueya Wang, Marco Colombi
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The Evolution of Acetyl-CoA Synthase
Origins of life and evolution of the biosphere, 2001Acetyl-coenzyme A synthases (ACS) are Ni-Fe-S containing enzymes found in archaea and bacteria. They are divisible into 4 classes. Class I ACS's catalyze the synthesis of acetyl-CoA from CO2 + 2e-, CoA, and a methyl group, and contain 5 types of subunits (alpha, beta, gamma, delta, and epsilon).
P A, Lindahl, B, Chang
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