Results 261 to 270 of about 214,689 (295)

Inhibitors of Mammalian Acetyl-CoA Carboxylase

Recent Patents on Cardiovascular Drug Discovery, 2007
Inhibition of acetyl-CoA carboxylase (ACC), with its resultant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation, has the potential to favorably affect, in a concerted manner, a multitude of the cardiometabolic risk factors associated with diabetes, obesity, and the metabolic syndrome.
Jeffrey W, Corbett, James H, Harwood
openaire   +2 more sources

The acetyl-CoA transporter family SLC33

Pfl�gers Archiv European Journal of Physiology, 2004
The acetyl-CoA (Ac-CoA) transporter (AT-1) is a multiple transmembrane protein in the endoplasmic reticulum. Ac-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins.
Yoshio, Hirabayashi, Akiko, Kanamori, Kazuko H, Nomura, Kazuya, Nomura   +3 more
openaire   +2 more sources

Autocatalytic activation of acetyl-CoA synthase

JBIC Journal of Biological Inorganic Chemistry, 2004
Acetyl-CoA synthase (ACS identical with ACS/CODH identical with CODH/ACS) from Moorella thermoacetica catalyzes the synthesis of acetyl-CoA from CO, CoA, and a methyl group of a corrinoid-iron-sulfur protein (CoFeSP). A time lag prior to the onset of acetyl-CoA production, varying from 4 to 20 min, was observed in assay solutions lacking the low ...
Ernest L, Maynard, Xiangshi, Tan, Paul A, Lindahl   +2 more
openaire   +2 more sources

Regulation of mammalian acetyl-CoA carboxylase

Biochemical Society Transactions, 2002
Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCα and ACCβ, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible ...
openaire   +2 more sources

Sources of Acetyl-CoA: Acetyl-CoA Synthetase 1 and 2

Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2003
Takahiro Fujino, Yukio Ikeda, Timothy Osborne, Sadao Takahashi, Tokuo Yamamoto, Juro Sakai   +5 more
openaire   +1 more source

Plant acetyl-CoA carboxylase

Biochemical Society Transactions, 1986
A, Hellyer, H E, Bambridge, A R, Slabas
openaire   +2 more sources

Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae

Bioresource Technology, 2021
Weizhu Zeng, Sha Xu, Jingwen Zhou
exaly  

Synthesis of acetyl‐CoA and acetyl‐dephospho‐CoA by acetyl‐CoA synthetase in the rat

Journal of Neurochemistry, 1978
H, Banns, C, Hebb, S P, Mann
openaire   +2 more sources

Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA

Molecular Cell, 2022
Shaobai Li, Mi Cao, Yafeng Shen
exaly  

The participation of acetyl-CoA in pyruvate carboxylase

Biochemical and Biophysical Research Communications, 1966
T G, Cooper, C R, Benedict
openaire   +2 more sources