Results 251 to 260 of about 250,937 (292)

Inhibitors of Mammalian Acetyl-CoA Carboxylase

Recent Patents on Cardiovascular Drug Discovery, 2007
Inhibition of acetyl-CoA carboxylase (ACC), with its resultant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation, has the potential to favorably affect, in a concerted manner, a multitude of the cardiometabolic risk factors associated with diabetes, obesity, and the metabolic syndrome.
Jeffrey W, Corbett, James H, Harwood
openaire   +2 more sources

Regulation of mammalian acetyl-CoA carboxylase

Biochemical Society Transactions, 2002
Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCα and ACCβ, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible ...
openaire   +2 more sources

The acetyl-CoA transporter family SLC33

Pfl�gers Archiv European Journal of Physiology, 2004
The acetyl-CoA (Ac-CoA) transporter (AT-1) is a multiple transmembrane protein in the endoplasmic reticulum. Ac-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins.
Yoshio, Hirabayashi, Akiko, Kanamori, Kazuko H, Nomura, Kazuya, Nomura   +3 more
openaire   +2 more sources

Autocatalytic activation of acetyl-CoA synthase

JBIC Journal of Biological Inorganic Chemistry, 2004
Acetyl-CoA synthase (ACS identical with ACS/CODH identical with CODH/ACS) from Moorella thermoacetica catalyzes the synthesis of acetyl-CoA from CO, CoA, and a methyl group of a corrinoid-iron-sulfur protein (CoFeSP). A time lag prior to the onset of acetyl-CoA production, varying from 4 to 20 min, was observed in assay solutions lacking the low ...
Ernest L, Maynard, Xiangshi, Tan, Paul A, Lindahl   +2 more
openaire   +2 more sources

The acetyl-CoA transporter family SLC33

Molecular Aspects of Medicine, 2013
The acetyl-CoA (Ac-CoA) transporter, ACATN is a multiple (11 or 12) transmembrane protein in the endoplasmic reticulum. Ac-CoA is transported into the lumen of the endoplasmic reticulum/Golgi apparatus, where it serves as the substrate of acetyltransferases that modify a variety of molecules including the sialic acid residues of gangliosides and lysine
Yoshio, Hirabayashi, Kazuko H, Nomura, Kazuya, Nomura   +2 more
openaire   +2 more sources

Sources of Acetyl-CoA: Acetyl-CoA Synthetase 1 and 2

Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2003
Takahiro Fujino, Yukio Ikeda, Timothy Osborne, Sadao Takahashi, Tokuo Yamamoto, Juro Sakai   +5 more
openaire   +1 more source

Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae

Bioresource Technology, 2021
Sha Xu, Zhou Jw, Weizhu Zeng
exaly  

Plant acetyl-CoA carboxylase

Biochemical Society Transactions, 1986
A, Hellyer, H E, Bambridge, A R, Slabas
openaire   +2 more sources

Synthesis of acetyl‐CoA and acetyl‐dephospho‐CoA by acetyl‐CoA synthetase in the rat

Journal of Neurochemistry, 1978
H, Banns, C, Hebb, S P, Mann
openaire   +2 more sources

Enhanced production of acetyl-CoA-based products via peroxisomal surface display in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, 2022
Nancy da Silva, Shane Bassett, Hannah Yocum   +2 more
exaly