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The acetyl-CoA transporter family SLC33
Pfl�gers Archiv European Journal of Physiology, 2004The acetyl-CoA (Ac-CoA) transporter (AT-1) is a multiple transmembrane protein in the endoplasmic reticulum. Ac-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins.
Yoshio, Hirabayashi +3 more
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Autocatalytic activation of acetyl-CoA synthase
JBIC Journal of Biological Inorganic Chemistry, 2004Acetyl-CoA synthase (ACS identical with ACS/CODH identical with CODH/ACS) from Moorella thermoacetica catalyzes the synthesis of acetyl-CoA from CO, CoA, and a methyl group of a corrinoid-iron-sulfur protein (CoFeSP). A time lag prior to the onset of acetyl-CoA production, varying from 4 to 20 min, was observed in assay solutions lacking the low ...
Ernest L, Maynard +2 more
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Inhibitors of Mammalian Acetyl-CoA Carboxylase
Recent Patents on Cardiovascular Drug Discovery, 2007Inhibition of acetyl-CoA carboxylase (ACC), with its resultant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation, has the potential to favorably affect, in a concerted manner, a multitude of the cardiometabolic risk factors associated with diabetes, obesity, and the metabolic syndrome.
Jeffrey W, Corbett, James H, Harwood
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Effect of insulin on association of acetyl CoA carboxylase phosphatase and acetyl CoA carboxylase
Biochemical and Biophysical Research Communications, 1985Insulin promotes an association between acetyl CoA carboxylase and acetyl CoA carboxylase phosphatase. The association between rat epididymal fat tissue carboxylase and the phosphatase occurs in both a tissue culture system and in vivo and is accompanied by an increase in acetyl CoA carboxylase activity.
G R, Krakower, K H, Kim
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Regulation of mammalian acetyl-CoA carboxylase
Biochemical Society Transactions, 2002Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCα and ACCβ, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible ...
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Biochemical Society Transactions, 1986
A, Hellyer, H E, Bambridge, A R, Slabas
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A, Hellyer, H E, Bambridge, A R, Slabas
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1969
Publisher Summary The chapter describes the purification procedure, assay methods, and properties of acetyl-coA synthetase. This enzyme is highly purified from yeast extracts and from beef heart mitochondria. The chapter discusses the extraction of enzyme especially from the latter procedure.
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Publisher Summary The chapter describes the purification procedure, assay methods, and properties of acetyl-coA synthetase. This enzyme is highly purified from yeast extracts and from beef heart mitochondria. The chapter discusses the extraction of enzyme especially from the latter procedure.
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Acetyl-CoA Carboxylase Inhibitors
2002Two important groups of herbicides, the cyclohexanediones (CHD) and aryloxyphenoxypropanoates (AOPP), inhibit the plastidic enzyme acetyl-CoA carboxylase (ACCase; E.C. 6.4.1.2). Representative compounds in these groups are shown in Fig. 1. A third class of inhibitor, based on a hybrid cyclic triketone structure, shows similar herbicidal activity ...
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Sources of Acetyl-CoA: Acetyl-CoA Synthetase 1 and 2
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2003Takahiro Fujino +5 more
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