Results 131 to 140 of about 38,176 (241)

Direct AMPK Activation Confers Mutation‐Independent Therapeutic Benefit in Duchenne Muscular Dystrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is a severe, life‐limiting neuromuscular disorder (NMD) characterized by progressive muscle wasting and mitochondrial dysfunction. Although gene therapies offer promise, even those already approved by regulatory agencies, their use remains constrained by mutation specificity, delivery challenges and
Sean Y. Ng, Andrew I. Mikhail, Stephanie R. Mattina, Magda A. Lesinski, Irena A. Rebalka, Sophie I. Hamstra, Donald Xhuti, Val A. Fajardo, Mark A. Tarnopolsky, Joshua P. Nederveen, Gregory R. Steinberg, Thomas J. Hawke, Vladimir Ljubicic   +12 more
wiley   +1 more source

Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 310-327, February 2026.
ABSTRACT Conventional Magnetic Resonance Imaging (MRI) offers limited sensitivity for direct metabolic and molecular imaging using non‐proton nuclei due to low thermal nuclear spin polarization. Hyperpolarization (HP) technologies increase nuclear spin polarization by several orders of magnitude, overcoming this limitation to enable in vivo studies of ...
Alixander S. Khan, Christoffer Laustsen
wiley   +1 more source

Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland [PDF]

, 1979
D. Grahame Hardie, Philip Cohen
openalex   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B

, 2014
Molly A. Silvers, Molly Silvers
openalex   +2 more sources

Regulation of eukaryotic acetyl-CoA carboxylases

, 2018
Many biological carboxylation reactions are catalyzed by ubiquitous biotin-dependent carboxylases. Their mechanism involves three conserved functional components; First, a biotin moiety, covalently linked to the biotin carboxyl carrier protein (BCCP) is carboxylated under ATP consumption at the biotin carboxylase (BC). Then the BCCP translocates to the
openaire   +3 more sources

Carboxydotrophic Acetogenesis in Alkaline Conditions Results in Transient Formate Production by the Halo‐Alkaliphilic Acetogen Haloacetibacter carboxydivorans Gen. Nov. sp. Nov

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This work presents the physiological exploration of the halo‐alkaliphilic, carboxydotrophic acetogen bacterium MD4. In contrast to well‐characterised neutrophilic and slightly acidophilic acetogenic carboxydotrophs, this work shows an important role for formate production, instead of ethanol, as a redox exhaust mechanism in alkaline conditions ...
Martijn Diender, Isabelle M. Keijsers, Anastasia Galani, Timo van Roosmalen, Alfons J. M. Stams, Diana Z. Sousa   +5 more
wiley   +1 more source

Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl‐CoA carboxylase 2 [PDF]

, 2013
Sungjo Park, In‐Wook Hwang, Yu Makishima, Ester Perales‐Clemente, Tatsuya Kato, Nicolas J. Niederländer, Enoch Y. Park, André Terzic   +7 more
openalex   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

, 2012
Makoto Kamata, Takashi Yamashita, Asato Kina, Masaaki Funata, Atsushi Mizukami, Masako Sasaki, Akiyoshi Tani, Miyuki Funami, Nobuyuki Amano, K. Fukatsu   +9 more
openalex   +1 more source