Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity [PDF]
, 1984 Michael R. Munday, D. Grahame Hardie
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Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model
The FEBS Journal, EarlyView.Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Andria Theodoulou +8 more
wiley +1 more source
The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
Frontiers in Bioscience-LandmarkCoenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie +4 more
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The quest for the best target genes for RNAi‐mediated pest control
Insect Molecular Biology, EarlyView.A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
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Determination of the quantity of acetyl CoA carboxylase by [14C]methyl avidin binding
Journal of Lipid Research, 1987 Conditions are described under which monomeric [14C]methyl avidin binds to SDS-denatured biotin enzymes and remains bound through polyacrylamide gel electrophoresis. The location of radioactive proteins on the dried gel was determined by fluorography and
C R Roman-Lopez, J Goodson, J B Allred
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Studies on the assay, activity and sedimentation behaviour of acetyl-CoA carboxylase from isolated hepatocytes incubated with insulin or glucagon [PDF]
, 1984 K. F. Buechler +2 more
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Journal of Phycology, EarlyView.Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner +3 more
wiley +1 more source
Targeting acetyl-CoA carboxylases for the treatment of MASLD
Journal of Lipid ResearchHepatic accumulation of triglycerides is a hallmark feature of metabolic dysfunction-associated steatotic liver disease (MASLD). Growing evidence indicates that increased rates of de novo lipogenesis (DNL) is one of the earliest metabolic changes promoting hepatic steatosis in the onset of MASLD.
María Antonia Mateo-Marín +1 more
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The Genome of Lolium multiflorum Reveals the Genetic Architecture of Paraquat Resistance
Molecular Ecology, EarlyView.ABSTRACT Herbicide resistance in agricultural weeds has become one of the greatest challenges for sustainable crop production. The repeated evolution of herbicide resistance provides an excellent opportunity to study the genetic and physiological basis of the resistance phenotype and the evolutionary responses to human‐mediated selection pressures ...
Caio A. Brunharo +3 more
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Fluazifop, a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species [PDF]
, 1988 openalex +1 more source