Results 161 to 170 of about 86,728 (368)

Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism [PDF]

, 2018
Aims/hypothesis: Pancreatic beta cells chronically exposed to fatty acids may lose specific functions and even undergo apoptosis. Generally, lipotoxicity is triggered by saturated fatty acids, whereas unsaturated fatty acids induce lipodysfunction, the ...
Bartley, C., Bosco, D., Brun, T., Frigerio, F., Maechler, P., Mandrup, S., Ravnskjær, K., Usardi, A.   +7 more
core  

Targeting acetyl-CoA carboxylases for the treatment of MASLD

Journal of Lipid Research
Hepatic accumulation of triglycerides is a hallmark feature of metabolic dysfunction-associated steatotic liver disease (MASLD). Growing evidence indicates that increased rates of de novo lipogenesis (DNL) are one of the earliest metabolic changes promoting hepatic steatosis in the onset of MASLD.
María Antonia Mateo-Marín, Michele Alves-Bezerra   +1 more
openaire   +3 more sources

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat

Proceedings of the National Academy of Sciences of the United States of America, 2002
Shaoxing Huang, A. Sirikhachornkit, X. Su, J. Faris, B. Gill, R. Haselkorn, P. Gornicki   +6 more
semanticscholar   +1 more source

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

Journal of Hepatology, 2020
J. Bates, A. Vijayakumar, Sarani Ghoshal, B. Marchand, Saili Yi, D. Kornyeyev, A. Zagórska, D. Hollenback, Katie Walker, Kathy Liu, Swetha Pendem, D. Newstrom, R. Brockett, I. Mikaelian, Saritha Kusam, Ricardo Ramírez, David Lopez, Li Li, B. Fuchs, D. Breckenridge   +19 more
semanticscholar   +1 more source

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, EarlyView.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source

The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

Frontiers in Bioscience-Landmark
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao   +4 more
doaj   +1 more source

The PEP—pyruvate—oxaloacetate node as the switch point for carbon flux distribution in bacteria: We dedicate this paper to Rudolf K. Thauer, Director of the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, on the occasion of his 65th birthday [PDF]

, 2017
In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally entangled set of reactions that interconnects the major pathways of carbon metabolism and thus, is responsible for the ...
Eikmanns, Bernhard J., Sauer, Uwe
core  

Optimization of carbon and nitrogen utilization for enhanced photosynthesis, biomass and yield by coexpression of phosphoenolpyruvate carboxylase, aspartate aminotransferase and glutamine synthetase in Brassica juncea

Plant Biotechnology Journal, EarlyView.
Summary Coexpression of genes involved in carbon (C) and nitrogen (N) metabolism offers a promising avenue for improving crop yield. This study investigated the impact of coexpressing phosphoenolpyruvate carboxylase [ZmPEPC (P)], aspartate aminotransferase [GmAspAT (A)] and glutamine synthetase [NtGS (G)] in Brassica juncea to enhance plant yield ...
Mamta, Shiv Shanker Pandey, Anish Kaachra, Sachin Vashisath, Dinesh Kumar, Sanjay Kumar   +5 more
wiley   +1 more source

Acetyl-CoA carboxylase (ACCase)-inhibiting herbicides: Past, present, and future

Weed Technology
Acetyl-CoA carboxylase (ACCase)-inhibiting herbicides are primarily applied for controlling grass weeds in broadleaf crops. These herbicides are foliar-active, providing minimal residual weed control.
Amit J. Jhala, Mandeep Singh, Debalin Sarangi, Lovreet Shergill, Aniruddha Maity, Zahoor A. Ganie, Chandrima Shyam, Mithila Jugulam, Jason K. Norsworthy   +8 more
doaj   +1 more source