Results 161 to 170 of about 146,351 (241)
Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu +11 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.The splicing of phenoxypyridine moieties to isoquinolin‐3‐carboxylic acid enhanced its biological activity against plant pathogenic fungi. Among target compounds, compound X6 demonstrated significant antifungal activity against Botrytis cinerea in vitro and in vivo assays, Molecular docking, molecular dynamics simulations, as well as SDH enzyme assay ...
Jiayao Zhang +7 more
wiley +1 more source
Purification of acetyl CoA carboxylase and change of enzyme activities by trypsin treatment
, 1989 의학과/석사[한글] Acetyl CoA carboxylase는 생체 내에서 단기적으로는 cirtrate 및 isocitrate에 의해서 활성화되면 장기적으로는 nutritional 또는 hormonal state에 따라서 조절된다고 보고되어 있다. 그러나 생체 외에서는 cirtrate나 isocitrate에 의해서 뿐만 아니라 tryspin처리시 또는 오랜 시간 동안의 냉장고 내 보관시에도 그 활성도가 증가한다는 사실도 보고되어 있으나 그 ...
최종환
core
4‐Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.4‑OHT directly inhibits AKR1B10 enzymatic activity to induce noncanonical ferroptosis in LUAD. AKR1B10 sustains LUAD survival by stabilising ACC1 and detoxifying reactive carbonyl species (RCSs). Nanatinostat similarly targets AKR1B10 and elicits the same cell death modality.
Hui Yang +8 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 9, September 2026.Biofilm microbial composition varies significantly; diversity is higher in spring and autumn. The dewatered reach shows the broadest niche and dominant stochastic assembly. Seasonal assembly shift: deterministic in summer, stochastic in winter. Nutrient cycling genes vary more among sites than seasons under SHP influence.
Huimin Gao +8 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications
Food Frontiers, Volume 7, Issue 5, September 2026.The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 9, September 2026.Summary of the systematic review and meta‐analysis of randomized controlled trials evaluating the effects of bergamot (Citrus bergamia) supplementation on cardiometabolic risk factors in adults. ABSTRACT Cardiovascular diseases remain the leading cause of global mortality.
Mahla Chambari +7 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 9, September 2026.These findings demonstrate that with adequate protein intake, graded short‐term EL (20%–40%) effectively improves hepatic lipid metabolism and modulates gut microbiota composition in overweight/obese mice, although these regulatory effects exhibit pronounced sex‐specific differences.
Ying Tian +6 more
wiley +1 more source