Results 51 to 60 of about 86,728 (368)

Allosteric Regulation Alters Carrier Domain Translocation in Pyruvate Carboxylase [PDF]

, 2018
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. The reaction occurs in two separate catalytic domains, coupled by the long-range translocation of a biotinylated carrier domain (BCCP). Here, we use a series
Budelier, Melissa M., Liu, Yumeng, St. Maurice, Martin, Stine, Katelyn   +3 more
core   +3 more sources

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

Proceedings of the National Academy of Sciences of the United States of America, 2002
gACRP30, the globular subunit of adipocyte complement-related protein of 30 kDa (ACRP30), improves insulin sensitivity and increases fatty acid oxidation. The mechanism by which gACRP30 exerts these effects is unknown.
E. Tomás, T. Tsao, A. Saha, H. Murrey, C. Zhang, Samar I. Itani, H. Lodish, N. Ruderman   +7 more
semanticscholar   +1 more source

Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by phosphorylation [PDF]

, 2019
Protein phosphorylation and membrane proteins play an important role in the infection of plants by phytopathogenic fungi, given their involvement in signal transduction cascades.
Amil, Francisco, Blanco-Ulate, Barbara, Cantoral Fernández, Jesús Manuel, Carrasco, Rafael, Chiva, Cristina, Escobar Niño, Almudena, Fernández Acero, Francisco Javier, Fuentes, Carlos, Lineiro, Eva, Sabido, Eduard   +9 more
core   +2 more sources

Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model

Journal of Pharmacology and Experimental Therapeutics, 2021
Acetyl-CoA carboxylase (ACC) 1 and ACC2 are essential rate-limiting enzymes that synthesize malonyl-CoA (M-CoA) from acetyl-CoA. ACC1 is predominantly expressed in lipogenic tissues and regulates the de novo lipogenesis flux.
Yumiko Okano Tamura, Jun Sugama, S. Iwasaki, Masako Sasaki, Hironobu Yasuno, Kazunobu Aoyama, Masanori Watanabe, D. Erion, H. Yashiro   +8 more
semanticscholar   +1 more source

Inhibition of rat liver acetyl CoA carboxylase by chloride

Journal of Lipid Research, 1980
The activity of acetyl CoA carboxylase in both crude and purified rat liver preparations was reduced in the presence of sodium or potassium chloride and increased in the presence of potassium acetate.
J B Allred, K L Roehrig
doaj   +1 more source

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase. [PDF]

, 2015
Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3 ...
Huang, Christine S, Jurado, Ashley R, Tong, Liang, Zhang, Xing, Zhou, Z Hong   +4 more
core   +2 more sources

Structural classification of biotin carboxyl carrier proteins [PDF]

, 2012
We gathered primary and tertiary structures of acyl-CoA carboxylases from public databases, and established that members of their biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains occur in one family each and that members of ...
Cantu, David, Chen, Yingfei, Elizondo-Noriega, Armando, Reilly, Peter, Reilly, Peter   +4 more
core   +3 more sources

Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression

Journal of Lipid Research, 2003
Hamsters were fed a control diet or diets containing palm, olive, safflower, or fish oil for 2 weeks. In villus cell populations from duodenum, jejunum, and ileum, rates of intestinal fatty acid and cholesterol synthesis were estimated, as were sterol ...
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

The Distinctive Regulatory Mechanisms of Bacterial Acetyl-CoA Carboxylase [PDF]

, 2018
Metabolic Regulation is a complex system used to control cellular metabolism in response to conditions in the cell’s environment. For most enzymes, the cell can rely upon a minimal amount of regulation; however, critical enzymes, such as acetyl-CoA ...
Evans, Alexandra Leigh
core   +2 more sources

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.

Journal of the American Society of Nephrology, 2018
BACKGROUND Expression of genes regulating fatty acid metabolism is reduced in tubular epithelial cells from kidneys with tubulointerstitial fibrosis (TIF), thus decreasing the energy produced by fatty acid oxidation (FAO). Acetyl-CoA carboxylase (ACC), a
Mardiana Lee, M. Katerelos, Kurt Gleich, S. Galic, B. Kemp, P. Mount, D. Power   +6 more
semanticscholar   +1 more source