Results 71 to 80 of about 42,990 (270)

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

Frontiers in Cellular Neuroscience, 2018
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy   +7 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The subcellular localization of acetyl-CoA carboxylase 2 [PDF]

Proceedings of the National Academy of Sciences, 2000
Animals, including humans, express two isoforms of acetyl-CoA carboxylase (EC 6.4.1.2 ), ACC1 ( M r = 265 kDa) and ACC2 ( M r = 280 kDa). The predicted amino acid sequence of ACC2 contains an additional 136 aa relative to ACC1, 114 of which ...
L, Abu-Elheiga, W R, Brinkley, L, Zhong, S S, Chirala, G, Woldegiorgis, S J, Wakil   +5 more
openaire   +2 more sources

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

A Biotin Analog Inhibits Acetyl-CoA Carboxylase Activity and Adipogenesis

, 2002
Acetyl-CoA carboxylase catalyzes the first committed step in the synthesis of long chain fatty acids. In this study, we observed that treatment of 3T3-L1 cells with biotin chloroacetylated at the 1\u27 nitrogen reduced the enzymatic activity of cytosolic
Jacqueline M. Stephens, Levert, Keith L, Waldrop, Grover L, Grover L. Waldrop, Keith L. Levert, Stephens, Jacqueline M   +5 more
core   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Expression of genes encoding acetyl-CoA carboxylase, biotin synthase, and acetyl-CoA generating enzymes in Arabidopsis thaliana

, 1997
Acetyl-CoA carboxylase catalyzes the formation of malonyl-CoA from acetyl-CoA. The four genes encoding heteromeric acetyl-CoA carboxylase are coordinately expressed in leaves, flowers, and developing siliques and embryos. The highest expression occurs in
Ke, Jinshan
core   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase

, 1998
An insulin-stimulated protein kinase specific for acetyl-CoA carboxylase has been purified from rat epididymal adipose tissue using Mono-Q chromatography.
Moule, S.K, R.M Denton, Heesom, KJ, Denton, RM, Heesom, K.J, K.J Heesom, Moule, SK, S.K Moule, Denton, R.M   +8 more
core   +1 more source

ACCase cross-resistance in Italian ryegrass (Lolium multiflorum) sub-populations from Oregon, US

Julius-Kühn-Archiv, 2012
ACCase-resistant Italian ryegrass (Lolium multiflorum) is one of the most troublesome weeds in US wheat production systems. This study had the objective of determining the resistance pattern of three subpopulations selected from a winter wheat field with
Barbosa Martins, Bianca Assis, Sanchez-Olguin, Elena, Perez-Jones, Alejandro, Mallory-Smith, Carol   +3 more
doaj   +1 more source