Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes [PDF]
, 1987 An assay is described for acetyl-CoA carboxylase activity in isolated hepatocytes. The assay is based on two principles: (a) The hepatocytes are made permeable by digitonin.
Bijleveld, C., Geelen, M.J.H.
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Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
Interdisciplinary Medicine, EarlyView.For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang +13 more
wiley +1 more source
Rapid induction of hepatic acetyl-CoA carboxylase activity after estradiol benzoate injection in the quail [PDF]
, 1981 The time course of hepatic Acetyl-CoA carboxylase activity as well as hepatic and plasmatic fatty acids concentrations following a single injection of estradiol benzoate (EB, 0.2 mg/kg) was studied in the quail.
Pageaux, Jean François +5 more
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The subcellular localization of acetyl-CoA carboxylase 2 [PDF]
Proceedings of the National Academy of Sciences, 2000 Animals, including humans, express two isoforms of acetyl-CoA carboxylase (EC 6.4.1.2 ), ACC1 ( M r = 265 kDa) and ACC2 ( M r = 280 kDa). The predicted amino acid sequence of ACC2 contains an additional 136 aa relative to ACC1, 114 of which ...
L, Abu-Elheiga +5 more
openaire +2 more sources
Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells
Interdisciplinary Medicine, EarlyView.Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen +6 more
wiley +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Nutritional regulation of stearoyl-CoA desaturase in the bovine mammary gland [PDF]
, 2011 Increasing the proportion of unsaturated fatty acids (UFA) in milk is believed to be beneficial in terms of human health, thereby increasing the nutritional quality of milk.
Jacobs, A.A.A.
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Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase [PDF]
, 2016 Acetyl-CoA carboxylase (ACC) is a target of interest for the treatment of metabolic syndrome. Starting from a biphenyloxadiazole screening hit, a series of piperazine oxadiazole ACC inhibitors was developed.
Kevin Salyers (1533250) +16 more
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Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh +3 more
wiley +1 more source
Regulation of rat liver acetyl CoA carboxylase [PDF]
, 1986 Acetyl-CoA carboxylase was purified 750-fold from rat liver cytosol using a modified purification procedure involving high speed ultracentrifugation, sucrose density step gradients, ion-exchange chromatography and avidin-sepharose affinity chromatography.
Quayle, Katherine Amanda
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