Results 81 to 90 of about 146,351 (241)

Nutritional regulation of stearoyl-CoA desaturase in the bovine mammary gland [PDF]

, 2011
Increasing the proportion of unsaturated fatty acids (UFA) in milk is believed to be beneficial in terms of human health, thereby increasing the nutritional quality of milk.
Jacobs, A.A.A.
core  

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes [PDF]

, 1987
An assay is described for acetyl-CoA carboxylase activity in isolated hepatocytes. The assay is based on two principles: (a) The hepatocytes are made permeable by digitonin.
Bijleveld, C., Geelen, M.J.H.
core   +1 more source

Reconsidering the impact of saturated fat intake on metabolic health: A critical review of evidence and controversies

Food Biomacromolecules, EarlyView.
Abstract Saturated fats (SFAs) play a complex role in health; therefore, their intake has been a topic of debate in the field of nutrition science. Therefore, this article emphasizes the importance of a balanced diet rather than SFA, considering genetic and metabolic differences, and advocates for the reconsideration of dietary guidelines based on the ...
Akash Kumar, Dipak S. Thorat, Sangeeta Yadav, Pooja Yadav, Jhilam Pramanik, Yogesh V. Ushir, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
wiley   +1 more source

Elevating acetyl-CoA levels reduces aspects of brain aging

eLife, 2019
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121
Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher   +8 more
doaj   +1 more source

A Biotin Analog Inhibits Acetyl-CoA Carboxylase Activity and Adipogenesis

, 2002
Acetyl-CoA carboxylase catalyzes the first committed step in the synthesis of long chain fatty acids. In this study, we observed that treatment of 3T3-L1 cells with biotin chloroacetylated at the 1\u27 nitrogen reduced the enzymatic activity of cytosolic
Jacqueline M. Stephens, Levert, Keith L, Waldrop, Grover L, Grover L. Waldrop, Keith L. Levert, Stephens, Jacqueline M   +5 more
core   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Expression of genes encoding acetyl-CoA carboxylase, biotin synthase, and acetyl-CoA generating enzymes in Arabidopsis thaliana

, 1997
Acetyl-CoA carboxylase catalyzes the formation of malonyl-CoA from acetyl-CoA. The four genes encoding heteromeric acetyl-CoA carboxylase are coordinately expressed in leaves, flowers, and developing siliques and embryos. The highest expression occurs in
Ke, Jinshan
core   +1 more source

The polymerization of acetyl-CoA carboxylase.

Journal of Biological Chemistry, 1983
Citrate, an allosteric activator of acetyl-CoA carboxylase, induces polymerization of an inactive protomeric form of the enzyme into an active filamentous form composed of 10-20 protomers. The light-scattering properties of the carboxylase were used to study the kinetics of its polymerization and depolymerization.
N B, Beaty, M D, Lane
openaire   +2 more sources

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +1 more source