The polymerization of acetyl-CoA carboxylase.
Journal of Biological Chemistry, 1983 Citrate, an allosteric activator of acetyl-CoA carboxylase, induces polymerization of an inactive protomeric form of the enzyme into an active filamentous form composed of 10-20 protomers. The light-scattering properties of the carboxylase were used to study the kinetics of its polymerization and depolymerization.
N B, Beaty, M D, Lane
openaire +2 more sources
Cloning of human acetyl‐CoA carboxylase cDNA [PDF]
European Journal of Biochemistry, 1994 Acetyl‐CoA carboxylase is the rate‐limiting enzyme in the biogenesis of long‐chain fatty acids. In order to understand the mechanisms that regulate human acetyl‐CoA carboxylase at the gene level, and the relationship between its structure and function, cDNA clones for human acetyl‐CoA carboxylase have been isolated and sequenced.
J, Ha +5 more
openaire +2 more sources
Study of the Effect of N-terminal mEGFP Tagging on the Enzymatic Activity and Cellular Localization of Human Acetyl-CoA Carboxylase 1 [PDF]
, 2023 Acetyl-CoA carboxylase 1 is the rate-limiting enzyme of fatty acid synthesis. It carboxylates acetyl-CoA to form malonyl-CoA in an ATP-dependent manner.
Zhang, Linsheng
core +1 more source
Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
Mediators of Inflammation, 1993 Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of ...
Keerang Park +2 more
doaj +1 more source
Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase.
PLoS ONE, 2020 Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial infections.
Erica C Larson +7 more
doaj +1 more source
Phosphorylation of pea chloroplast acetyl‐CoA carboxylase [PDF]
The Plant Journal, 1999 SummaryWe have examined whether chloroplast acetyl‐CoA carboxylase is a phosphoprotein. Pea (Pisum sativum) chloroplasts were incubated in the presence of [γ‐33P]‐ATP and radiolabeled proteins were examined after immunoprecipitation with antibodies against all four known subunits of heteromeric chloroplast acetyl‐CoA carboxylase.
, Savage, , Ohlrogge
openaire +2 more sources
Constituents of cinnamon inhibit bacterial acetyl CoA carboxylase [PDF]
, 2010 Cinnamon bark (Cinnamomum zeylanicum) is used extensively as an antimicrobial material and currently is being increasingly used in Europe by people with type II diabetes to control their glucose levels.
Henken, Rachel L. +13 more
core +1 more source
The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain
Frontiers in Cellular Neuroscience, 2018 Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska +7 more
doaj +1 more source
We set the objective function of the constructed models to the given reactions (acetyl-CoA synthetase and acetyl-CoA carboxylase reactions) and turned the lower bound to zero for maximizing the production and regulation reaction of acetyl-CoA. [PDF]
, 2014 The producing reaction of acetyl-CoA is catalyzed by acetyl-CoA synthetase, which is in turn regulated by acetyl-CoA carboxylase, an enzyme which catalyzes acetyl CoA conversion to malonyl-CoA, the first and rate-limiting reaction in de novo synthesis of
Ali Akbar Saboury (233129) +3 more
core +1 more source
Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, EarlyView.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source