Results 61 to 70 of about 82,191 (356)

Cloning of human acetyl‐CoA carboxylase cDNA [PDF]

European Journal of Biochemistry, 1994
Acetyl‐CoA carboxylase is the rate‐limiting enzyme in the biogenesis of long‐chain fatty acids. In order to understand the mechanisms that regulate human acetyl‐CoA carboxylase at the gene level, and the relationship between its structure and function, cDNA clones for human acetyl‐CoA carboxylase have been isolated and sequenced.
Ki-Han Kim, Hyi-Jeong Tae, Samira Daniel, In-Soo Kong, Chung-Kil Park, Joohun Ha   +5 more
openaire   +3 more sources

Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA

Computational and Structural Biotechnology Journal, 2022
Malonyl-CoA is an energy-rich molecule formed by the ATP-dependent carboxylation of acetyl coenzyme A catalyzed by acetyl-CoA carboxylase. This molecule is an important precursor for many biotechnologically interesting compounds such as flavonoids ...
Humberto Pereira, Flávio Azevedo, Lucília Domingues, Björn Johansson   +3 more
doaj  

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

eLife, 2018
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear.
S. Galic, K. Loh, L. Murray‐Segal, G. Steinberg, Z. Andrews, B. Kemp   +5 more
semanticscholar   +1 more source

A tale of two functions: enzymatic activity and translational repression by carboxyltransferase [PDF]

, 2009
Acetyl-CoA Carboxylase catalyzes the first committed step in fatty acid synthesis. Escherichia coli acetyl-CoA carboxylase is composed of biotin carboxylase, carboxyltransferase and biotin carboxyl carrier protein functions.
Anne Grove, Bai, Bao, Benson, Bilder, Blanchard, Blattner, Brian K. Benson, Chu, Chu, Cleland, Cronan, Glen Meades, Grover L. Waldrop, Hamed, Hensley, Ho, Holden, James, Ke, Kozaki, Li, Li, Lorenz, Nikolau, Selinger, Sun, Sundararaj, Takamura, Voeller   +29 more
core   +3 more sources

In silico identification of potential inhibitors of acyl carrier protein reductase and acetyl CoA carboxylase of Plasmodium falciparum in antimalarial therapy

Frontiers in Drug Discovery, 2023
Malaria caused by Plasmodium falciparum, remains one of the most fatal parasitic diseases that has affected nearly a third of the world’s population. The major impediment to the treatment of malaria is the emergence of resistance of the P.
Elliasu Y. Salifu, James Abugri, James Abugri, Issahaku A. Rashid, Festus Osei, Joseph Atia Ayariga   +5 more
doaj   +1 more source

Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland [PDF]

, 2005
We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited
Barber, Michael C., Binart, Nadine, Flint, David J., Kelly, Paul A., Travers, Maureen T.   +4 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development

Cell Death and Disease, 2022
Skeletal muscle is the largest metabolic organ in the body, and its metabolic flexibility is essential for maintaining systemic energy homeostasis. Metabolic inflexibility in muscles is a dominant cause of various metabolic disorders, impeding muscle ...
Bolin Cai, Manting Ma, Jing Zhang, Shaofen Kong, Zhen Zhou, Zhenhui Li, Bahareldin Ali Abdalla, Haiping Xu, Xiquan Zhang, Raman Akinyanju Lawal, Qinghua Nie   +10 more
doaj   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

MTFR2‐Mediated Fission Drives Fatty Acid and Mitochondrial Co‐Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis

Advanced Science, EarlyView.
In the tumor margin of hepatocellular carcinoma (HCC), activated hepatic stellate cells upregulate MTFR2, initiating inhibiting DRP1 degradation and mitochondrial fission. This enhances mitochondrial availability and facilitates FAs synthesis via ACC1. Additionally, fission promotes RAC1‐mediated cytoskeletal remodeling and Miro1‐mediated mitochondrial
La Zhang, Baoyong Zhou, Jun Yang, Cong Ren, Jing Luo, Zhenghang Li, Qiang Liu, Zuotian Huang, Zhongjun Wu, Ning Jiang   +9 more
wiley   +1 more source