Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, Volume 7, Issue 3, June 2026.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
Mitochondrial Citrate Transporters CtpA and YhmA Are Required for Extracellular Citric Acid Accumulation and Contribute to Cytosolic Acetyl Coenzyme A Generation in Aspergillus luchuensis mut. kawachii. [PDF]
Appl Environ Microbiol, 2019 Kadooka C +8 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.Supplement users have lower epigenetic biological age than non‐users. Several supplements or supplement classes are associated with some benefit on epigenetic age in either cross‐sectional or longitudinal analyses. ABSTRACT In this cross‐sectional cohort we analyzed data from 4260 “health enthusiasts” who purchased at least one saliva‐based DNA ...
Kamil Pabis +6 more
wiley +1 more source
THE NET ENZYMATIC SYNTHESIS OF ACETYL COENZYME A
Journal of Biological Chemistry, 1952 openaire +2 more sources
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Low adiponectin levels may contribute to insulin resistance. This first‐in‐human study evaluated adiponectin receptor agonist (PEG)‐BHD1028 in subjects with insulin resistance. Adults with BMI ≥ 27 kg/m2, HOMA‐IR ≥ 1.8, and HbA1c < 6.5% received subcutaneous injections of (PEG)‐BHD1028 or placebo in single‐ascending dose (SAD) cohorts (4, 8 ...
Pablo Lapuerta, Brian B. Kim
wiley +1 more source
Protein acetylation and acetyl coenzyme a metabolism in budding yeast. [PDF]
Eukaryot Cell, 2014 Galdieri L +4 more
europepmc +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6‐methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic analyses revealed a negative correlation between fat mass and obesity‐associated protein (FTO) and LUR1 expression and abundant m6A sites within the ...
Xiang‐Yang Tang +5 more
wiley +1 more source
Allelic Diversity of Acetyl Coenzyme A Carboxylase accD/bccp Genes Implicated in Nuclear-Cytoplasmic Conflict in the Wild and Domesticated Pea (Pisum sp.). [PDF]
Int J Mol Sci, 2019 Nováková E +8 more
europepmc +1 more source
Energy Stress‐Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Energy stress via glucose deprivation activates AMPK and protects dopaminergic neurons from ferroptosis by limiting lipid peroxidation. In contrast, glucose availability supports ferroptosis through oxidizable lipid pools. ABSTRACT Ferroptosis, an iron‐dependent form of regulated necrosis, is implicated in the pathogenesis of Parkinson's disease (PD ...
Aurélie Jonneaux +8 more
wiley +1 more source