Results 191 to 200 of about 118,012 (240)

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

open access: yesJournal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan   +2 more
wiley   +1 more source

Skin Boosters: 2026 Updated

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi   +7 more
wiley   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

open access: yesMolecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang   +12 more
wiley   +1 more source

Systemic Delivery of Functional Proteins Into Plants Using an Engineered Membrane Translocation Domain

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3939-3952, June 2026.
ABSTRACT Protein‐based biopesticides and biostimulants are critical for the future of sustainable agriculture, yet their utility is severely limited by inefficient delivery into plant cells. Traditional cell‐penetrating peptides enable protein uptake but lack the efficiency, systemic activity and scalability required for crop production.
Jiyang Wang   +12 more
wiley   +1 more source

Overexpression of cytosolic NADP‐malic enzyme 1 from the common ice plant enhances water‐deficit and high‐light stress tolerance by modulating water‐use efficiency and flavonoid biosynthesis

open access: yesThe Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY Innovative strategies are essential to enhance crop resilience against drought and heat stress intensified by climate change. Crassulacean acid metabolism (CAM) is a specialized photosynthetic pathway that improves water‐use efficiency (WUE) by shifting CO2 fixation to the nighttime. The common ice plant (Mesembryanthemum crystallinum) utilizes
Sang Hun Kim   +5 more
wiley   +1 more source

Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin‐Like Lasso Peptide

open access: yesChemBioChem, Volume 27, Issue 10, 27 May 2026.
Biosynthesis of the class V lasso peptide gelatinamin A was elucidated by heterologous expression of the gel biosynthetic gene cluster in Bacillus subtilis. Its 3D structure was determined by NMR, and tailoring enzymes GelT and GelP were fully reconstituted in vitro.
Tiziana Svenningsen   +9 more
wiley   +1 more source

Publication Only

open access: yes
HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs. [PDF]

open access: yesMolecules
Voukia F   +3 more
europepmc   +1 more source

Fluoroquinolone-Induced Metabolic Dysregulation and Oxidative Stress Orchestrate Bacterial Demise. [PDF]

open access: yesMicroorganisms
Zhou C   +10 more
europepmc   +1 more source

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