Results 111 to 120 of about 25,053 (234)

A Novel 9‐Channel 1H, 3‐Channel 31P Radiofrequency Coil for Interleaved Multinuclear Studies of Human Calf Muscle at 7 T

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3008-3020, May 2026.
ABSTRACT Purpose To develop a double‐tuned calf coil with excellent 1H and 31P performance to study muscle physiology by interleaved 1H/31P MRS and parallel imaging at 7 T. Methods The coil combines three 1H transceive dipoles, six 1H receive‐only loops and three 31P transceive loops, arranged in a nested, half‐cylindrical layout.
Veronika Cap, Vasco Rafael Rocha dos Santos, Kostiantyn Repnin, Onisim Soanca, Elmar Laistler, Peter Wolf, Graham J. Kemp, Roberta Frass‐Kriegl, Martin Meyerspeer   +8 more
wiley   +1 more source

Morphological and Redox/Glycative Alterations in the PCOS Oviducts: Modulating Effects of Carnitines in PCOS Mice

Biology
Polycystic ovarian syndrome (PCOS) is a heterogeneous condition characterized by hyperandrogenism (HA), polycystic ovaries, and dysfunctional ovulation, and it is associated with metabolic problems such as insulin resistance (IR) and obesity.
Mariacarla De Rubeis, Ilaria Antenisca Mascitti, Domenica Cocciolone, Martina Placidi, Teresa Vergara, Giovanna Di Emidio, Guido Macchiarelli, Carla Tatone, Stefania Annarita Nottola, Maria Grazia Palmerini   +9 more
doaj   +1 more source

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins

Cell Reports, 2016
Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction.
Michael N. Davies, Lilja Kjalarsdottir, J. Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M. Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, Deborah M. Muoio   +9 more
doaj   +1 more source

Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions [PDF]

, 2013
Mitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid composition and displaying transverse as well as lateral asymmetry.
Jurado, A. S., Monteiro, João P., Oliveira, Paulo J.   +2 more
core   +1 more source

Downregulation of Organ‐Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting.
Cui Wang, Lin Gao, Rui Xue, Jia Su, Honghui Li, Wei Yang, Yan Tang, Zhihang Su, Shasha Min, Changyong Tang, Yuqi Zhu, Bo Mu, John R. Speakman, Xina Xie, Zesong Li   +14 more
wiley   +1 more source

Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study

NMR in Biomedicine, Volume 39, Issue 4, April 2026.
Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano, Carmen Marino, Manuela Grimaldi, Michela Buonocore, Angelo Santoro, Anna Maria D'Ursi   +5 more
wiley   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, Volume 65, Issue 4, Page 706-723, April 2026.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian, Ricky R Lareu, Mohan Patil, Marco Falasca   +3 more
wiley   +1 more source

Correction to: Retrospective observational study on the use of acetyl-L-carnitine in ALS. [PDF]

J Neurol, 2023
Sassi S, Bianchi E, Diamanti L, Tornabene D, Sette E, Medici D, Matà S, Leccese D, Sperti M, Martinelli I, Ghezzi A, Mandrioli J, Iuzzolino VV, Dubbioso R, Trojsi F, Passaniti C, D'Alvano G, Filosto M, Padovani A, Mazzini L, De Marchi F, Zinno L, Nuredini A, Bongioanni P, Dolciotti C, Canali E, Toschi G, Petrucci A, Perna A, Riso V, Inghilleri M, Libonati L, Cambieri C, Pupillo E.   +33 more
europepmc   +1 more source

Weight Loss During Obesity Provokes Asparaginase‐Associated Liver Steatosis and Endoplasmic Reticulum Stress

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Lean mice and DIO mice were fed either a low‐fat maintenance diet (MD) or a high‐fat obesogenic diet (OD) during pegylated asparaginase exposure. OD exacerbated asparaginase‐induced weight loss and modestly increased liver triglycerides and ER stress in lean mice.
Chintan T. Bhavsar, Brian A. Zalma, Keigo Tomoo, Yi Zhang, Esther M. Lopez, Emily T. Mirek, Joseph L. Dixon, Gregory C. Henderson, Ronald C. Wek, Tracy G. Anthony   +9 more
wiley   +1 more source