Acetyl-L-Carnitine in Attention-Deficit/Hyperactivity Disorder: A Multi-Site, Placebo-Controlled Pilot Trial [PDF]
, 2007 Objective: To determine whether acetyl-L-carnitine (ALC), a metabolite necessary for energy metabolism and essential fatty acid anabolism, might help attention-deficit/hyperactivity disorder (ADHD). Trials in Down’s syndrome, migraine, and Alzheimer’s
Amato, Antonino +13 more
core +1 more source
Acetyl-L-carnitine in chronic pain: A narrative review
Pharmacological Research, 2021 Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy metabolism, but also has antioxidant properties, protects from oxidative stress, modulates brain neurotransmitters such as acetylcholine, serotonin and dopamine, and acts on neurotrophic factors such as nerve growth factor (NGF) and metabotropic glutamate (mGlu ...
Sarzi-Puttini P. +3 more
openaire +2 more sources
Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update
Frontiers in Medicine, 2021 Carnitine is an amino acid-derived substance that coordinates a wide range of biological processes. Such functions include transport of long-chain fatty acids from the cytoplasm to the mitochondrial matrix, regulation of acetyl-CoA/CoA, control of inter ...
Na Li, Na Li, Hui Zhao
doaj +1 more source
Scientific Reports, 2021 To understand the characteristic of changes of serum metabolites between healthy people and patients with hepatitis B virus (HBV) infection at different stages of disease, and to provide reference metabolomics information for clinical diagnosis of liver ...
Hui Li +5 more
doaj +1 more source
Biomedicines, 2023 Carnitines play a key physiological role in oocyte metabolism and redox homeostasis. In clinical and animal studies, carnitine administration alleviated metabolic and reproductive dysfunction associated with polycystic ovarian syndrome (PCOS).
Martina Placidi +10 more
doaj +1 more source
Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-l-carnitine [PDF]
, 2016 The aim of the present study was to investigate the efficacy of acetyl-l-carnitine (ALCAR) on pathologic changes of mitochondrial respiratory chain activity, ATP production, oxidative stress, and cellular apoptosis/necrosis induced by aluminum phosphide (
Abdolghaffari, A.H. +9 more
core +1 more source
Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism [PDF]
, 2013 Peer reviewedPublisher ...
Calignano, A +6 more
core +4 more sources
Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality [PDF]
Iranian Journal of Reproductive Medicine, 2012 Background: Sperm cells extracted from testes (TESE) have poor chromatin quality and motility. Various substances are used in the laboratory to increase sperm motility and improve the ART outcomes; however, there are few research which considered ...
Elham Aliabadi +5 more
doaj
Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. [PDF]
Cochrane Database Syst Rev, 2019 Diabetic peripheral neuropathy (DPN) is a common and severe complication that affects 50% of people with diabetes. Painful DPN is reported to occur in 16% to 24% of people with diabetes. A complete and comprehensive management strategy for the prevention and treatment of DPN, whether painful or not, has not yet been defined.Research into treatment for ...
Rolim LC +4 more
europepmc +4 more sources
Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
core +1 more source