Results 51 to 60 of about 25,053 (234)

l-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway

Journal of Orthopaedic Surgery and Research, 2023
Background Knee osteoarthritis (KOA) is a disability-associated condition that is rapidly growing with the increase in obesity rates worldwide. There is a pressing need for precise management and timely intervention in the development of KOA. l-carnitine
Taiyang Liao, Wei Mei, Li Zhang, Liang Ding, Nan Yang, Peimin Wang, Li Zhang   +6 more
doaj   +1 more source

Multiple dietary supplements do not affect metabolic and cardio-vascular health [PDF]

, 2013
Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory
Fontana, Luigi, Holloszy, John O, Soare, Andreea, Weiss, Edward P   +3 more
core   +3 more sources

The neurobiology of acetyl-L-carnitine

Frontiers in Bioscience, 2016
A large body of evidence points to the positive effects of dietary supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism ...
openaire   +3 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Carnitines as Mitochondrial Modulators of Oocyte and Embryo Bioenergetics

Antioxidants, 2022
Recently, the importance of bioenergetics in the reproductive process has emerged. For its energetic demand, the oocyte relies on numerous mitochondria, whose activity increases during embryo development under a fine regulation to limit ROS production ...
Martina Placidi, Giovanna Di Emidio, Ashraf Virmani, Angela D’Alfonso, Paolo Giovanni Artini, Anna Maria D’Alessandro, Carla Tatone   +6 more
doaj   +1 more source

Untargeted metabolomics to reveal red versus white meat‐associated gut metabolites in a prudent and western dietary context [PDF]

, 2020
Scope: To improve understanding of the epidemiological link between red and processed meat consumption and chronic diseases, more insight in the formation of metabolites during meat digestion is warranted.Methods and results: Untargeted MS ...
De Smet, Stefaan, Goethals, Sophie, Hemeryck, Lieselot, Rombouts, Caroline, Van Camp, John, Van Hecke, Thomas, Van Meulebroek, Lieven, Vanhaecke, Lynn, Vossen, Els   +8 more
core   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

L-carnitine supplementation in female infertility – is it working?

Journal of Education, Health and Sport, 2023
Introduction and objective: Infertility is estimated to affect around 15% of couples in reproductive age. Due to delayed decision about childbearing and unhealthy lifestyle it is increasing problem in many western countries. For that reason, people seek
Paulina Laskus, Jakub Przeradzki, Katarzyna Rząd, Aleksandra Borycka, Maria Kotulska, Zofia Potocka, Martyna Lichman, Zuzanna Lubczyńska, Barbara Jędrzejewska   +8 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics [PDF]

, 2009
Background. Resting and postprandial oxidative stress is elevated in those with metabolic disorders such as diabetes. Antioxidant supplementation may attenuate the rise in oxidative stress following feeding.
Richard J Bloomer, Kelsey H Fisher-Wellman, Patrick S Tucker   +2 more
core   +1 more source