Results 191 to 200 of about 48,976 (299)

Holocarboxylase Synthetase Deficiency: A Second Case Report With Neonatal Cholestatic Liver Disease

open access: yesJIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Holocarboxylase synthetase deficiency is an autosomal recessive inborn error of metabolism characterised by life‐threatening metabolic acidosis, ketoacidosis and hyperammonaemia through reduced biotin‐dependent carboxylase activity. We report the presentation of a Polynesian neonate with severe metabolic acidosis secondary to holocarboxylase ...
Sophie Manoy   +9 more
wiley   +1 more source

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model. [PDF]

open access: yesHepatol Commun, 2020
Gapp B   +15 more
europepmc   +1 more source

Structural basis of product recognition by Mycobacterium tuberculosis fatty acid synthase

open access: yesProtein Science, Volume 35, Issue 1, January 2026.
Abstract Microbial iterative fatty acid synthases (FAS) are versatile multienzymes under scrutiny for their potential as anti‐infectious targets and their biotechnological applications. They produce saturated fatty acids with defined chain length and release them as coenzyme A‐conjugates.
Elnaz Khalili Samani   +4 more
wiley   +1 more source

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. [PDF]

open access: yesCell Metab, 2019
Son SM   +6 more
europepmc   +1 more source

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

open access: yesPest Management Science, Volume 82, Issue 1, Page 151-168, January 2026.
Crystallographic fragment screening of A. thaliana FatA yielded 141 hits and along with orthogonal assays, this enables the target for rapid development of novel chemical matter to the currently available herbicides. Abstract BACKGROUND In order to alleviate the growing issue of herbicide resistance, diversification of the herbicide portfolio is ...
Ekaterina Kot   +15 more
wiley   +1 more source

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