Results 171 to 180 of about 50,102 (223)

Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells. [PDF]

Sci Rep, 2019
Farrugia G, Azzopardi M, Saliba C, Grech G, Gross AS, Pistolic J, Benes V, Vassallo N, Borg J, Madeo F, Eisenberg T, Balzan R.   +11 more
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Extending the Scope of ¹H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A. [PDF]

Anal Chem, 2019
Nagana Gowda GA, Abell L, Tian R.
europepmc   +1 more source

Riboflavin Salvage Supports Glycolysis in Borrelia burgdorferi Through Flavin‐Dependent NAD+ Regeneration

Molecular Microbiology, Volume 126, Issue 2, Page 208-219, August 2026.
The Lyme disease agent Borrelia burgdorferi has limited metabolic capabilities and depends on salvage of riboflavin via the BB0316‐BB0319 transport system for generation of critical flavin cofactors FMN and FAD. Riboflavin is important for NAD+ regeneration to fuel glycolysis.
Anna M. Schulz, Grace E. Easterling, Aaditya Balasubramaniyan, Mollie W. Jewett   +3 more
wiley   +1 more source

Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts

Experimental Physiology, Volume 111, Issue 8, Page 3635-3647, 1 August 2026.
Abstract Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate‐specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high‐fat diet and low‐dose streptozotocin.
Toan Pham
wiley   +1 more source

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model. [PDF]

Hepatol Commun, 2020
Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I.   +15 more
europepmc   +1 more source

Metformin Partially Attenuates Simvastatin‐Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Simvastatin induces metabolic suppression, mitochondrial dysfunction, and atrophy‐related responses in skeletal muscle cells. In differentiated C2C12 myotubes, metformin partially attenuates these alterations by preserving myotube structural integrity, reducing cellular stress signaling, and maintaining mitochondrial network organization despite ...
Chuqi He, Mike Wesselink, Jelle Y. Huijts, Zhenjia Zhong, Moritz Eggelbusch, Richard T. Jaspers, Rob C. I. Wüst   +6 more
wiley   +1 more source

Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design. [PDF]

Nat Commun, 2019
Lu X, Liu Y, Yang Y, Wang S, Wang Q, Wang X, Yan Z, Cheng J, Liu C, Yang X, Luo H, Yang S, Gou J, Ye L, Lu L, Zhang Z, Guo Y, Nie Y, Lin J, Li S, Tian C, Cai T, Zhuo B, Ma H, Wang W, Ma Y, Liu Y, Li Y, Jiang H.   +28 more
europepmc   +1 more source

Berberine and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Hope or Hype?

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Ruth Nona, Eric Kalo
wiley   +1 more source