Results 151 to 160 of about 50,102 (223)

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. [PDF]

Nature
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY.   +12 more
europepmc   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, Volume 65, Issue 8, Page 963-976, August 2026.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103⁺ T Cells. [PDF]

Adv Sci (Weinh)
Lei J, Ji H, Guo J, Liu M, Su D, Zheng Y, Xu L, Cao Q, Ren T, Gui J, Wen Z.   +10 more
europepmc   +1 more source

Acetyl Coenzyme A Carboxylase

Journal of Biological Chemistry, 1970
Richard Jacobs, Elisabeth Kilburn, Philip W. Majerus   +2 more
openaire   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Assessing Acetyl-Coenzyme A Carboxylase Activity and Inhibition in <i>Caenorhabtidis elegans</i> Using a Partially Purified Protein Extract. [PDF]

Anal Chem
Battaglia G, Hunashal Y, Gopinadhan S, Gan HH, Moussa Y, Mohammed Refai FS, Amoresano A, Fahs HZ, Gunsalus KC, Esposito G, Piano F.   +10 more
europepmc   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases. [PDF]

ACS Pharmacol Transl Sci
Ewida H, Benson H, Tareq S, Ahmed MS.
europepmc   +1 more source

On the Origin of the Brain Semi‐Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 862-870, August 2026.
ABSTRACT Purpose To evaluate the extent to which the appearance of HOD in the brain following systemic administration of a deuterated substrate is due to local brain metabolism versus body metabolism. Methods [6,6‐2H2]glucose, which is transported across the blood‐brain barrier (BBB), and [6,6‐2H2]fructose (Fruc), which does not cross the BBB, were ...
Joseph J. H. Ackerman, Xia Ge, Nick Rensing, Jeffrey J. Neil, Liu Lin Thio, Joel R. Garbow   +5 more
wiley   +1 more source

Mixed Valence {Ni²⁺Ni¹⁺} Clusters as Models of Acetyl Coenzyme A Synthase Intermediates. [PDF]

J Am Chem Soc
Wilson DWN, Thompson BC, Collauto A, Hooper RX, Knapp CE, Roessler MM, Musgrave RA.   +6 more
europepmc   +1 more source