Results 151 to 160 of about 113,995,962 (231)

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103⁺ T Cells. [PDF]

Adv Sci (Weinh)
Lei J, Ji H, Guo J, Liu M, Su D, Zheng Y, Xu L, Cao Q, Ren T, Gui J, Wen Z.   +10 more
europepmc   +1 more source

Assessing Acetyl-Coenzyme A Carboxylase Activity and Inhibition in <i>Caenorhabtidis elegans</i> Using a Partially Purified Protein Extract. [PDF]

Anal Chem
Battaglia G, Hunashal Y, Gopinadhan S, Gan HH, Moussa Y, Mohammed Refai FS, Amoresano A, Fahs HZ, Gunsalus KC, Esposito G, Piano F.   +10 more
europepmc   +1 more source

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

Glia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden, David John Calkins   +1 more
wiley   +1 more source

INDUCTION OF PEROXISOMAL FATTY ACYL-COENZYME A-OXIDASE AND TOTAL CARNITINE ACETYL-COENZYME A-TRANSFERASE IN PRIMARY CULTURES OF RAT HEPATOCYTES BY GARLIC EXTRACTS

, 1992
Garlic has been proposed as a natural hypolipidemic substance. Most hypolipidemic compounds induce peroxisomal proliferation and increase enzyme activities associated with peroxisomal beta-oxidation in rat liver.
BRONFMAN, M, MORALES, MN, KAWADA, ME, ORELLANA, A, VARGAS, L   +4 more
core  

Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases. [PDF]

ACS Pharmacol Transl Sci
Ewida H, Benson H, Tareq S, Ahmed MS.
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2713-2728, October 2026.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Mixed Valence {Ni²⁺Ni¹⁺} Clusters as Models of Acetyl Coenzyme A Synthase Intermediates. [PDF]

J Am Chem Soc
Wilson DWN, Thompson BC, Collauto A, Hooper RX, Knapp CE, Roessler MM, Musgrave RA.   +6 more
europepmc   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source