Results 91 to 100 of about 9,200 (244)
A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice
Aging Cell, Volume 25, Issue 3, March 2026.A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid +6 more
wiley +1 more source
PLoS ONE, 2020 BackgroundLow carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration and is a model for simulating insulin resistance and metabolic ...
Yvonne M H Bruls +10 more
doaj +1 more source
BMC Medicine, 2021 Background Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast ...
Mathilde His +35 more
doaj +1 more source
Dual effects of fibroblast growth factor 21 on hepatic energy metabolism [PDF]
, 2015 The aim of this study was to investigate the mechanisms by which FGF21 affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in their
Adams, Andrew C. +9 more
core +2 more sources
An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study
The Journal of Physiology, Volume 604, Issue 5, Page 1872-1896, 1 March 2026.Abstract figure legend An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study Abstract Allostatic load scores (ALSs) quantify the cumulative physiological burden of sustained stress across neuro‐endocrine, metabolic, cardiovascular and inflammatory domains; however ALS is heterogeneous in nature.
Nevah Joubert +4 more
wiley +1 more source
Respiratory Research, 2023 Background Fatty acid oxidation (FAO) defects have been implicated in experimental models of acute lung injury and associated with poor outcomes in critical illness.
Tomeka L. Suber +13 more
doaj +1 more source
Neonatal cardiomyopathy and lactic acidosis responsive to thiamine [PDF]
, 1991 A congestive cardiomyopathy was diagnosed in a girl at the age of 4 weeks. In the weeks following she developed general muscle hypotonia and plasma lactate increased to 8.5 mmol/L.
Abeling, N.G.G.M. (Nicolaas) +5 more
core +2 more sources
Folia biologica, 2016 Some therapeutic and/or adverse effects of drugs may be related to their effects on mitochondrial function. The effects of simvastatin, resveratrol, coenzyme Q10, acetylcysteine, and acetylcarnitine on Complex I-, Complex II-, or Complex IV-linked ...
Z. Fišar +4 more
semanticscholar +1 more source
Physiological Reports, Volume 14, Issue 5, March 2026.Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez +10 more
wiley +1 more source
Relative contribution of intramyocellular lipid to whole-body fat oxidation is reduced with age but subsarcolemmal lipid accumulation and insulin resistance are only associated with overweight individuals [PDF]
, 2016 Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are associated with increasing age. It remains to be determined to what extent perturbations in IMCL metabolism are related to the aging process per se.
Aisling Burns +14 more
core +3 more sources