Results 101 to 110 of about 9,200 (244)

Deacylation of acetyl-coenzyme A and acetylcarnitine by liver preparations [PDF]

Biochemical Journal, 1978
The breakdown of acetylcarnitine catalysed by extracts of rat and sheep liver was completely abolished by Sephadex G-25 gel filtration, whereas the hydrolysis of acetyl-CoA was unaffected. Acetyl-CoA and CoA acted catalytically in restoring the ability of Sephadex-treated extracts to break down acetylcarnitine, which was therefore not due to an ...
A M, Snoswell, P K, Tubbs
openaire   +2 more sources

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

Biochemical Testing Promotes Interpretation of Variants of Uncertain Significance in Prenatal Genetic Disease Testing in Four Organic Acidurias

Clinical Genetics, Volume 109, Issue 2, Page 211-217, February 2026.
This review demonstrates how amniotic fluid biochemical testing provides critical phenotypic evidence (ACMG PP4) for reclassifying variants of uncertain significance (VUS) in prenatal organic acidurias. Integrating metabolite analysis with genetic testing enhances diagnostic accuracy and enables informed clinical decisions for affected families ...
Kaili Yin, Qingwei Qi
wiley   +1 more source

Hypoglycemia is not a defining feature of metabolic crisis in mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase deficiency: Further evidence of specific biochemical markers which may aid diagnosis

JIMD Reports, 2020
Mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG Co‐A) synthase (mHS) deficiency is an autosomal recessive disorder of ketone body synthesis which has traditionally been associated with hypoketotic hypoglycemia, hepatomegaly and encephalopathy ...
Tracey A. Conlon, Patricia E. Fitzsimons, Ingrid Borovickova, Fidelma Kirby, Sinéad Murphy, Ina Knerr, Ellen Crushell   +6 more
doaj   +1 more source

Current state‐of‐the‐art hyperpolarized 13C‐acetate‐to‐acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes

Physiological Reports, 2016
Dear Editor, Indeed acetate trafficking matters, however, hyperpolarized 13C‐acetate‐to‐acetylcarnitine is unable to detect any significant alterations between healthy controls and type‐1 diabetic rat heart, liver, and kidney, respectively in the fed ...
Ulrich Koellisch, C. Laustsen, T. Nørlinger, J. Østergaard, A. Flyvbjerg, Concetta V. Gringeri, M. Menzel, R. Schulte, A. Haase, H. Stødkilde-Jørgensen   +9 more
semanticscholar   +1 more source

Brentuximab Vedotin With Adriamycin, Vinblastine, and Dacarbazine for Patients Aged 18–59 Years With Untreated Advanced Stage Classical Hodgkin Lymphoma: The Largest Real‐Life Series From Southern Italy Cancer Centers

European Journal of Haematology, Volume 116, Issue 2, Page 174-184, February 2026.
ABSTRACT BV + AVD is increasingly used for frontline treatment of stage III/IV cHL. Young adults and adults (Ya&A) were the most common patients treated with BV + AVD in clinical trials but have not been studied in non‐trial settings. We conducted a real‐life study in secondary and tertiary cancer centers to evaluate the PFS in 18–59 years aged ...
Marco Picardi, Annamaria Vincenzi, Claudia Giordano, Novella Pugliese, Alessia Scarpa, Assunta Lombardi, Elena Vigliar, Giancarlo Troncone, Rosaria Cappiello, Massimo Mascolo, Giovanni Esposito, Maria Prastaro, Ciro Santoro, Roberta Esposito, Carlo Gabriele Tocchetti, Ciro Mainolfi, Rosa Fonti, Silvana Del Vecchio, Fabio Trastulli, Mario Annunziata, Rossella Iula, Catello Califano, Marianna Carchia, Marcello Persico, Alessia Salemme, Emanuele Nicolai, Andrea Soricelli, Marco Salvatore, Fabrizio Pane   +28 more
wiley   +1 more source

Carbohydrate restriction drives greater perturbations in circulating metabolites than low energy availability in elite male athletes

Physiological Reports, Volume 14, Issue 3, February 2026.
Elite male race walkers underwent a 5 d dietary intervention of either high carbohydrate (HCHO), low‐carbohydrate high‐fat (LCHF), or low energy availability (LEA) to evaluate their metabolomic response. Following a standardized 25 km endurance walk, blood samples were collected across five timepoints, ranging from a fasted state to 3 h post‐exercise ...
Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K. A. McKay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke   +9 more
wiley   +1 more source

Body mass index and age correlate with antioxidant supplementation effects on sperm quality: Post hoc analyses from a double-blind placebo-controlled trial [PDF]

, 2020
Spermatozoa are vulnerable to lack of energy and oxidative stress as a result of elevated levels of reactive oxygen species. Therefore, it is essential that appropriate nutrients are available during maturation.
Agarwal, Ashok, Busetto, Gian Maria, Chung, Benjamin I, De Berardinis, Ettore, Del Giudice, Francesco, Ferro, Matteo, Maggi, Martina, Porreca, Angelo, Sciarra, Alessandro, Virmani, Ashraf   +9 more
core   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Enzymological determination of free carnitine concentrations in rat tissues

Journal of Lipid Research, 1964
Purified carnitine acetyltransferase was employed to catalyze the reaction:Carnitine+acetylCoA⇌acetylcarnitine+CoA. In the presence of a known excess of acetyl CoA, free CoA released was determined simultaneously in a coupled spectrophotometric assay ...
Norman R. Marquis, Irving B. Fritz
doaj   +1 more source