Results 111 to 120 of about 9,200 (244)

Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC–MS metabolomics [PDF]

, 2016
INTRODUCTION: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. OBJECTIVES: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys(10), Cys(13))) changed plasma metabolite levels ...
Burch, Kerry, Cowan, Elaine, Graham, Stewart F, Green, Brian, Grieve, David, Kumar, Praveen   +5 more
core   +1 more source

Carnitine and acetylcarnitine modulate mesenchymal differentiation of adult stem cells

Journal of Tissue Engineering and Regenerative Medicine, 2015
Cellular metabolic activity, especially mitochondrial metabolism, plays a vital role in regulating cell proliferation and differentiation. Metabolism could therefore be an important factor to consider when using engineering technologies to stimulate ...
Qiaozhi Lu, Yuanfan Zhang, J. Elisseeff
semanticscholar   +1 more source

Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 107-119, January/February 2026.
ABSTRACT Liquid chromatography‐mass spectrometry (LC–MS) is a powerful technique for the detection and quantification of methylated quaternary ammonium compounds (mQACs), such as acylcarnitines and methylated amino‐acid‐derived (betainized) compounds, in biological matrices.
Iman Zarei, Ambrin Farizah Babu, Ville M. Koistinen, Marjo Tuomainen, Anna Kårlund, Retu Haikonen, Marko Lehtonen, Kati Hanhineva   +7 more
wiley   +1 more source

Effects of including white clover and plantain species in perennial ryegrass pastures on qualitative indicators and metabolome of milk

International Journal of Dairy Technology, Volume 79, Issue 1, January–March 2026.
Mixed sward pasture systems are being investigated due to their potential to improve bio diversity and sustainability metrics; our study provides a due diligence on the impact of pastures containing perennial ryegrass, white clover and plantain species on the composition and functionality of milk.
Nisha J Suthar, Eoin Wims, Michael Dineen, Raghunath Pariyani, Denis Lynch, Lorraine M Bateman, David T Mannion, Anita R Maguire, Kieran N Kilcawley, James A O'Mahony, Tom F O'Callaghan   +10 more
wiley   +1 more source

The response of canine faecal microbiota to increased dietary protein is influenced by body condition [PDF]

, 2017
Background: High protein diets shift the faecal microbiota into a more unfavourable composition in obese humans. In lean dogs, higher protein consumption is accompanied with increased production of putrefactive fermentation products, whereas obese dogs ...
Campos, Miguel, Cools, An, Eeckhaut, Venessa, Hesta, Myriam, Liu, Daisy, Marzorati, Massimo, Ribeiro Alves Lourenço, Marta, Van de Wiele, Tom, Van Immerseel, Filip, Vanhaecke, Lynn, Verbrugghe, Adronie, Xu, Jia   +11 more
core   +3 more sources

Causal Relationships Between Plasma Metabolites, Inflammatory Factors, and Oral Cancer Risk: A Comprehensive Mendelian Randomization Study With Mediation Analysis

Human Mutation, Volume 2026, Issue 1, 2026.
This study conducted a large‐scale Mendelian randomization analysis using genome‐wide single nucleotide polymorphisms (SNPs) as instrumental variables to investigate the causal relationships between 1400 circulating metabolites and oral cancer risk. The genetic data were derived from the Canadian Longitudinal Study on Aging (CLSA) cohort and the IEU ...
Shaonan Hu, Chufeng Liu, Minghua Ren
wiley   +1 more source

Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles.

Biochimica et Biophysica Acta, 2014
Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase.
Y. Furuichi, N. Goto-Inoue, Y. Manabe, M. Setou, K. Masuda, N. Fujii   +5 more
semanticscholar   +1 more source

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]

, 2018
Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev, A Leibowitz, AA Ferrando, AA Smith, B Lecka-Czernik, C Fasolato, C Harteneck, C Morris, CL Hoppel, D Belelli, D Fietz, E Asmussen, E Chorell, E Pohjanen, G Lac, G Van Hall, GC Bogdanis, GD Lewis, GJ Rietjens, H Budde, H Budde, H Karlic, H Yokoyama, J Henriksson, JB Walker, JH Mitchell, JK Nicholson, JM Peake, JS Fuqua, K Goto, K Sahlin, K Sahlin, K Sato, K Sato, KR Howarth, LS Eriksson, ME Powers, MH Jacob, MH Williams, MJ Ormsbee, ML Circu, ML Goodwin, P Yin, PC Tullson, R Berton, RF Coburn, S Naz, SC Lu, SK Powers, TE Graham, W Dudzinska, YP Pitsiladis   +51 more
core   +1 more source

Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men

Environment International, 2019
Background: A growing body of evidence has found links between endocrine disruptor phthalates and male reproductive disorders, but the mechanisms underlying these relationships are poorly known.
Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarro, Jie Zhang, An Pan   +12 more
doaj   +1 more source

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

JCI Insight, 2023
BACKGROUND At the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skeletal ...
Rodrigo F. Mancilla, Lucas Lindeboom, Lotte Grevendonk, Joris Hoeks, Tim R. Koves, Deborah M. Muoio, Patrick Schrauwen, Vera Schrauwen-Hinderling, Matthijs K.C. Hesselink   +8 more
doaj   +1 more source