Results 201 to 210 of about 9,200 (244)

Potential Therapeutic Role of Carnitine and Acetylcarnitine in Neurological Disorders

Current Pharmaceutical Design, 2020
Background:Current therapy of neurological disorders has several limitations. Although a high number of drugs are clinically available, several subjects do not achieve full symptomatic remission. In recent years, there has been an increasing interest in the therapeutic potential of L-carnitine (LCAR) and acetyl-L-carnitine (ALCAR) because of the ...
Cecilia Maldonado, Marta Vázquez, Pietro Fagiolino   +2 more
openaire   +3 more sources

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC–mass spectrometry

Biomedical Chromatography, 2015
AbstractAcetyl‐l‐carnitine (ALCAR) is a potential biomarker for the modulation of brain neurotransmitter activity, but is also present in cerebrospinal fluid (CSF). Recent studies have utilized hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC‐MS/MS) based assays to detect and quantify ALCAR within biofluids such as urine ...
Brian R, Holder, Colleen A, McNaney, David, Luchetti, Eric, Schaeffer, Dieter M, Drexler   +4 more
openaire   +3 more sources

Post-contraction [Acetylcarnitine] Reflects Inter-individual Variation in Skeletal Muscle ATP Production Patterns in Vivo.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2023
In addition to its role in substrate selection (carbohydrate vs. fat) for oxidative metabolism in muscle, acetylcarnitine production may be an important modulator of the energetic pathway by which ATP is produced.
Christopher M T Hayden, Rajakumar Nagarajan, Z. Smith, Samantha L. Gilmore, Jane A. Kent   +4 more
semanticscholar   +1 more source

Using matrix-induced ion suppression combined with LC-MS/MS for quantification of trimethylamine-N-oxide, choline, carnitine and acetylcarnitine in dried blood spot samples.

Analytica Chimica Acta, 2021
Recently, there has been significant interest in the influences of the human gut microbiota on many diseases, such as cardiovascular disease (CVD) and metabolic disorders.
Wan-hui Lu, Huai-hsuan Chiu, Han-Chun Kuo, Guan-Yuan Chen, Divyabharathi Chepyala, C. Kuo   +5 more
semanticscholar   +1 more source

Acetylcarnitine Inhibits Alcohol Dehydrogenase

Biochemical and Biophysical Research Communications, 1994
Carnitine and acetylcarnitine are used as dietary supplements and as therapeutic agents. Carnitine attenuates ethanol metabolism in intact animals but the in vitro activities of alcohol dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) or catalase are not significantly altered by carnitine.
D S, Sachan, Y S, Cha
openaire   +2 more sources

Acetylcarnitine and Cholinergic Receptors

Journal of Pharmaceutical Sciences, 1980
Acetylcarnitine, a naturally occurring compound found in high concentration in heart and skeletal muscle of vertebrates, bears structural resemblance to acetylcholine, and studies have shown that it has slight cholinergic properties. Acetylcarnitine was subjected to conformational analysis by extended Hückel theory (EHT) and complete neglect of ...
K W, Reed, W J, Murray, E B, Roche
openaire   +2 more sources

Transient seizure activity induced by acetylcarnitine

Neuropharmacology, 1984
Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency
R G, Fariello, E, Zeeman, G T, Golden, P T, Reyes, T, Ramacci   +4 more
openaire   +2 more sources

l-Acetylcarnitine as a histone acetylation modulator in psychiatric disorders

Psychopharmacology, 2018
J. Peedicayil
openaire   +3 more sources

Acetylcarnitine increases membrane cytoskeletal protein-protein interactions

Life Sciences, 1993
Electron paramagnetic resonance has been used to investigate the effects of interaction of acetylcarnitine with cytoskeletal proteins in human erythrocyte membranes. This compound, currently in clinical trials as a potential therapeutic agent for Alzheimer's disease, caused a highly significant increase in cytoskeletal protein-protein interactions ...
D A, Butterfield, A, Rangachari
openaire   +2 more sources

Enzymatic determination of acetylcarnitine for diagnostic applications

Journal of Pharmaceutical and Biomedical Analysis, 2001
An enzymatic method was proposed for determination of acetylcarnitine (AcCar), even when carnitine (Car), non-acetylated form, co-exists. The method is consisted of four enzymatic reactions: First, AcCar is hydrolysed by acylcarnitine hydrolase to yield acetate; followed by the other three reactions coupled with three enzymes, respectively, acetate ...
K, Tomita, S, Sakurada, S, Minami
openaire   +2 more sources