Results 211 to 220 of about 9,200 (244)

Carnitine and acetylcarnitine in red blood cells

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
Carnitine and acetylcarnitine were found to be present in human erythrocytes. Their presence was not as a factor of leucocyte contamination. Carnitine is present within the erythrocyte at a level comparable to that of the plasma, whilst acetylcarnitine is more concentrated within the cell.
M B, Cooper, C A, Forte, D A, Jones
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A preparation and purification of [1-14C]acetylcarnitine

Analytical Biochemistry, 1992
[1-14C]Acetylcarnitine was prepared from [1-14C]acetate and L-carnitine using acetyl-CoA synthetase and carnitine acetyltransferase. The product was purified by ion-exchange and thin-layer chromatography. Conversion of [1-14C]acetate to [1-14C]acetylcarnitine was better than 90% and overall recovery of the pure product was greater that 80%.
G, Roughan, J, Browse
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Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study

Critical Care Medicine, 2019
Objectives: Recent metabolomic studies of sepsis showed that increased circulatory acylcarnitines were associated with worse survival. However, it is unknown whether plasma carnitine and acylcarnitines can reflect the severity of sepsis, and the role of ...
Kuei-Pin Chung, Guan-Yuan Chen, T. Chuang, Yen-Tsung Huang, Hou-Tai Chang, Yen-Fu Chen, Wei-Lun Liu, Yi-Jung Chen, Chia-Lin Hsu, Miao‐Tzu Huang, C. Kuo, Chong-Jen Yu   +11 more
semanticscholar   +1 more source

Acetylcarnitine formation during intense muscular contraction in humans

Journal of Applied Physiology, 1987
To study the changes in carnitine during intense muscular effort subjects underwent 4 min intermittent electrical stimulation of the quadriceps femoris muscle and on a separate occasion performed 4 min exercise on a bicycle ergometer. Biopsies of the vastus lateralis muscle were taken at rest and after 2 and 4 min of stimulation or exercise.
R C, Harris, C V, Foster, E, Hultman
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Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier.

Drug Metabolism And Disposition
Liver failure often causes hepatic encephalopathy, partly due to dysregulation in cerebral energy metabolism. Carnitine and acetylcarnitine play essential roles in energy metabolism by transporting fatty acids from the cytosol into mitochondria, whose ...
Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wen-han Wu, Lu Yang, Yidong Dai, Zehua Wang, Ling Jiang, Yongmei Tan, Xiaodong Liu, Li Liu   +10 more
semanticscholar   +1 more source

Simultaneous analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as potential plasma biomarkers to evaluate NSAIDs‐induced gastric injury by liquid chromatography–tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2019
Graphical abstract Figure. No Caption available. HighlightsLC–MS/MS analysis for simultaneous determination of 5 amino acids was developed.The assay was fully validated and applied to in vivo studies in rats and dogs.Proline, hydroxyproline, and ...
Soyoung Shin, Hyeon Myeong Jeong, S. Chung, Tae Hwan Kim, Subindra Kazi Thapa, Damho Lee, Chang Ho Song, Jun Young Lim, Sang-Min Cho, Kyu-Yeol Nam, Won-Ho Kang, Youn-Woong Choi, B. Shin   +12 more
semanticscholar   +1 more source

Acetylcarnitine: On the relationship between structure and function

Biochemical and Biophysical Research Communications, 1973
Abstract Acetylcarnitine chloride, a molecule with cholinergic properties, has been studied by X-ray crystallographic techniques. Results show that a portion of the acetylcarnitine molecule is in the same configuration as the functionally similar acetylcholine molecule and other cholinergic molecules.
R L, Sass, P, Werness
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Delaying the Mitochondrial Decay of Aging with Acetylcarnitine

Annals of the New York Academy of Sciences, 2004
Abstract: Oxidative mitochondrial decay is a major contributor to aging. Some of this decay can be reversed in old rats by feeding them normal mitochondrial metabolites, acetylcarnitine (ALC) and lipoic acid (LA), at high levels. Feeding the substrate ALC with LA, a mitochondrial antioxidant, restores the velocity of the reaction (Km) for ALC ...
Bruce N, Ames, Jiankang, Liu
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Acetylcarnitine-mediated inhibition of ethanol oxidation in hepatocytes

Alcohol, 1995
Carnitine-mediated prevention of ethanol-induced hepatic steatosis is related to the attenuation of ethanol metabolism by carnitine in the intact rat. Although carnitine retards ethanol oxidation in the intact animal, the in vitro activities of ethanol-metabolizing enzymes remain unaltered.
Y S, Cha, D S, Sachan
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Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis

BioFactors, 2009
AbstractModulation of endogenous cellular defense mechanisms via the stress response signaling represents an innovative approach to therapeutic intervention in diseases causing chronic damage, such as neurodegeneration and cancer. Protein thiols play a key role in redox sensing, and regulation of cellular redox state is crucial mediator of multiple ...
CALABRESE, Vittorio, CORNELIUS C, DINKOVA KOSTOVA A. T, CALABRESE E. J.   +3 more
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