Results 61 to 70 of about 9,200 (244)
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide [PDF]
, 2016 Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs.
Avery, Vicky M. +11 more
core +2 more sources
Heliyon, 2023 For a long time, co-products of food processing have been used in animal feed, but far less in fish because of their assumed inability to cope with high-fiber diets. Research on feeding co-products to fish species that naturally consume fibrous diets are
Awot Teklu Mebratu +4 more
doaj +1 more source
Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis [PDF]
, 2016 Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the
Barrett, Michael P. +7 more
core +5 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Molecular Metabolism, 2022 Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss.
Yvo J.M. op den Kamp +18 more
doaj +1 more source
Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding [PDF]
, 2016 Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing ...
A. Vaag, Allan +5 more
core +1 more source
L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies [PDF]
Current Neuropharmacology, 2006 During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved.
CHIECHIO, SANTINA +3 more
openaire +2 more sources
iMetaOmics, EarlyView.This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian +7 more
wiley +1 more source
Journal of Clinical Medicine, 2019 Introduction. In recent years, research has focused on the impact that diabetes mellitus (DM) has on male reproductive function. The available evidence has mainly considered type 2 DM (DM2).
R. Condorelli +7 more
semanticscholar +1 more source
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion [PDF]
, 2001 A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations.
Aynsley-Green, A +9 more
core