Results 161 to 170 of about 125,133 (347)

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype

Aging Cell, Volume 24, Issue 4, April 2025.
We sought to identify the cerebrospinal fluid protein (CSF) changes that are associated with the APOE4 genetic variant to better understand the vulnerability of APOE4 carriers to progress to Alzheimer's disease (AD) with age. To do this, we used machine learning and enrichment analyses to analyze 6082 proteins in the CSF of cognitively normal, mild ...
Artur Shvetcov, Shannon Thomson, Ann‐Na Cho, Heather M. Wilkins, Joanne H. Reed, Russell H. Swerdlow, David A. Brown, the Alzheimer's Disease Neuroimaging Initiative, Caitlin A. Finney   +8 more
wiley   +1 more source

CATECHOLAMINE AND ACETYLCHOLINESTERASE DISTRIBUTION IN RELATION TO NORADRENALINE RELEASE. AN ENZYME HISTOCHEMICAL AND AUTORADIOGRAPHIC STUDY ON THE INNERVATION OF THE CAT NICTITATING MUSCLE [PDF]

, 1968
A. C. Esterhuizen, John D. Graham, J. D. Lever, T. L. B. Spriggs   +3 more
openalex   +1 more source

SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
SGLT2 inhibition with Enavogliflozin significantly improves cognitive function and reduces Aβ pathology in the 5XFAD mouse model of Alzheimer's disease. Through AMPK activation, Enavogliflozin enhances microglial mitochondrial function and Aβ phagocytosis while reducing neuroinflammation.
Jihui Han, Jaehoon Song, Eun Sun Jung, Ji Won Choi, Hye Young Ji, Inhee Mook‐Jung   +5 more
wiley   +1 more source

Acetylcholinesterase-Containing Nerve Fibers in the Canine Kidney [PDF]

, 1968
Olivia C. McKenna, E. T. Angelakos
openalex   +1 more source

Developing an international concept‐based curriculum for pharmacology education: The promise of core concepts and concept inventories

British Journal of Clinical Pharmacology, EarlyView.
Abstract Over recent years, studies have shown that science and health profession graduates demonstrate gaps in their fundamental pharmacology knowledge and ability to apply pharmacology concepts in practice. This article reviews the current challenges faced by pharmacology educators, including the exponential growth in discipline knowledge and ...
Clare Guilding, Roisin Kelly‐Laubscher, Adeladlew Netere, Anna‐Marie Babey, Carolina Restini, Margaret Cunningham, John P. Kelly, Jennifer Koenig, Kelly Karpa, Martin Hawes, Steven J. Tucker, Thomas A. Angelo, Paul J. White   +12 more
wiley   +1 more source

Fine Structural Localization of Acetylcholinesterase at a Cholinergic Vasodilator Nerve-Arterial Smooth Muscle Synapse [PDF]

, 1969
Christopher Bell
openalex   +1 more source

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

Brain Pathology, EarlyView.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez, Muhammad Nadeem, Bin He, Jennifer C. Miguel, David G. Moreno, Marta Moreno‐Rodriguez, Michael Malek‐Ahmadi, Chadwick M. Hales, Elliott J. Mufson   +8 more
wiley   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

On the irreversible binding of p‐(trimethylammonium) benzenediazonium fluoroborate (TDF) to acetylcholinesterase from electrogenic tissue [PDF]

, 1969
Jean‐Claude Meunier, Jean‐Pierre Changeux   +1 more
openalex   +1 more source

In Vitro Acetylcholinesterase Inhibition by Type A Botulinum Toxin [PDF]

, 1967
Rosemarie Marshall, Loyd Y. Quinn
openalex   +1 more source