Results 151 to 160 of about 51,436 (262)

Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba, Jubilee Andrew, Donald Fernandes   +2 more
wiley   +1 more source

ACETYLCHOLINESTERASE

Journal of Biological Chemistry, 1951
openaire   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Conformationally locked 7-aryl tetrahydroisoquinolines as dual acetylcholinesterase inhibitors and antioxidants: role of intramolecular hydrogen bonding and aryl electronics. [PDF]

Front Pharmacol
Ríos V, Linares-Pipón C, Maulén C, Castro-Álvarez A, Bradshaw B, Romero-Parra J, Cuellar MA, Martínez-Cifuentes M, Parra C.   +8 more
europepmc   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Chemical Composition and Preliminary Screening of Anticholinesterase and Antioxidant Activities of the Essential Oil of <i>Ambrosia arborescens</i> Mill. from Southern Ecuador. [PDF]

Plants (Basel)
Calva J, Ramírez J.
europepmc   +1 more source

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A novel series of 5‐chloro‐N‐alkyl‐1′,1″‐dimethyl‐4′‐aryldispiro[indene‐2,3′‐pyrrolidine‐2′,3″‐indoline]−1,2″(3H)‐diones (4a–r) was rationally designed and synthesized via a one‐pot multicomponent reaction of N‐alkylated 5‐chloroisatin derivatives, 2‐(arylmethylidene)−2,3‐dihydro‐1H‐inden‐1‐ones (2a–i), and sarcosine (3).
Aisha A. Alsfouk, Riham A. El‐Shiekh, Benson M. Kariuki, Eman Sabry, Mohamed G. Abouelenein, Asmaa Saleh, Mahmoud G. A. Saleh, Aladdin M. Srour   +7 more
wiley   +1 more source

PFAS Compounds Display Distinct Toxicological Effects in <i>Drosophila melanogaster</i>, Reflected by Reduced Viability and Impaired Neuronal Function. [PDF]

Biomolecules
Luedtke K, Rocha CB, Svensson M, Brorsson AC.   +3 more
europepmc   +1 more source

An Efficient Method for Neuron‐Like Differentiation of SH‐SY5Y Neuroblastoma Cells Using Retinoic Acid and Laminin‐Rich Extracellular Matrix

genesis, Volume 64, Issue 4, August 2026.
ABSTRACT The human neuroblastoma cell line SH‐SY5Y is widely used in vitro as a model due to its ability to acquire neuron‐like properties. Conventional differentiation protocols often rely on retinoic acid (RA), which can lead to limited stability of neuronal‐like phenotypes over time.
Marina Mantellatto Grigoli, Bianca Cruz Pachane, Angelina Maria Fuzer, Sabrina Dorta de Oliveira, Ana Beatriz Aparecida Targas, Vanessa Alexandre‐Silva, Heloisa Sobreiro Selistre‐de‐Araujo, Patricia Regina Manzine, Marcia Regina Cominetti   +8 more
wiley   +1 more source

Design, synthesis, and insecticidal potency of novel 3-methyl-pyrazole derivatives against Culex pipiens larvae. [PDF]

Sci Rep
Nofal HR, Ali AK, Ismail MF, Kamal M, Hosni EM, Abbass EM.   +5 more
europepmc   +1 more source