Results 161 to 170 of about 75,116 (210)
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Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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Molecular Dynamics of Acetylcholinesterase
Accounts of Chemical Research, 2002Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site.
Shen, Tongye +3 more
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Canadian Journal of Biochemistry, 1964
The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
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The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
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Toward an Artificial Acetylcholinesterase
Chemistry - A European Journal, 2000The methanolysis of choline p-nitrophenylcarbonate in chloroform containing 1% methanol is catalyzed with turnover by ditopic receptors 1 and 2, consisting of a calix[6]arene connected to a bicyclic guanidinium by means of a short spacer. The calix[6]arene subunit strongly binds to the trimethylammonium head group through cation-pi interactions ...
CUEVAS F. +5 more
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Breathing Without Acetylcholinesterase
2004Acetylcholine (ACh) mediates neurotransmission at the neuromuscular junction and is involved in respiratory control1, notably chemosensitivity2 of central and peripheral origin. The level of ACh at the synaptic cleft and neuromuscular junction is regulated by the enzyme acetylcholinesterase (AChE).
Chatonnet, Fabrice +4 more
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Acetylcholinesterase in the human retina
Brain Research, 1987The distribution of cholinesterase activity in the human retina was evaluated using histochemical methods. The butyrylcholine esterase (BuChE) inhibitor tetraisopropylpyrophosphoramide was used to localize acetylcholinesterase (AChE) activity, the AChE inhibitor BW284c51 was used to localize BuChE activity, and eserine was used to inhibit all ...
J B, Hutchins, J G, Hollyfield
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Stereospecificity of erythrocyte acetylcholinesterase
Archives of Biochemistry and Biophysics, 1964Abstract Lactoylcholine is a choline ester which contains an asymmetric carbon atom in the acid portion of the molecule. A study of the hydrolytic rate of the enantiomers of this choline ester by human erythrocyte acetylcholinesterase revealed that the l (+) isomer is hydrolyzed at least four times greater than the d (−) isomer.
J V, AUDITORE, B V, SASTRY
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Activation of acetylcholinesterase by vanadate
Neuropharmacology, 1985Vanadate activated acetylcholinesterase in rat ventricular strips. This effect of probably due to the action of vanadate (V) form rather than to vanadyl (IV). Vanadate also activated purified acetylcholinesterase from the electric eel and also erythrocytes, suggesting a direct effect upon this enzyme system.
R E, Catalán +3 more
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Acetylcholinesterase in the Rabbit Cornea
Archives of Ophthalmology, 1965There is strong evidence that the acetylcholine system is responsible for the electric currents which propagate impulses in conducting tissues.1,2In the eye, high concentrations of acetylcholine have been reported in the corneal epithelium;3cholinesterase has been demonstrated in various other ocular tissues chemically4and histochemically;5,6and high ...
R A, PETERSEN, K J, LEE, A, DONN
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Plasma acetylcholinesterase activity
American Journal of Obstetrics and Gynecology, 1950Abstract ChE activity in plasma from normal adult nonmenstruating, nonpregnant women, from women during normal pregnancy, and from patients with toxemia of pregnancy was determined manometrically. Significant differences were observed among the three groups. This difference was independent of medication (Sodium Amytal), and could not be attributed to
W W, TOURTELLOTTE, L D, ODELL
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