Results 181 to 190 of about 176,114 (393)

Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′‐Bipyridine‐4,4′‐Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition

open access: yesChemistryOpen, EarlyView.
Two new 2,2′‐bipyridine‐4,4′‐dicarboxamide ligands and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. The L2‐Co complex shows strong antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Hussein Alchurak   +5 more
wiley   +1 more source

Rapid eye movement sleep deprivation induces an increase in acetylcholinesterase activity in discrete rat brain regions

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Some upper brainstem cholinergic neurons (pedunculopontine and laterodorsal tegmental nuclei) are involved in the generation of rapid eye movement (REM) sleep and project rostrally to the thalamus and caudally to the medulla oblongata.
Benedito M.A.C., Camarini R.
doaj  

Turnover Number of Acetylcholinesterase

open access: hybrid, 1961
Irwin B. Wilson, Mark A. Harrison
openalex   +1 more source

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

open access: yesChemistryOpen, EarlyView.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya   +8 more
wiley   +1 more source

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

Discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy and Implications in Movement Disorders

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Charles Palmer   +2 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

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